UniProt Accession

 KT3K_HUMAN; Q9HA64; Q969F4; Q9H0U7 

Genbank Protein ID

 AY360465; AL136631; AK022233; BC001458; BC007611; BC014408 

Genbank Nucleotide ID

 AAQ72344.1; CAB66566.1; BAB13992.1; AAH01458.2; AAH07611.1; AAH14408.1 

Protein Name

 Ketosamine-3-kinase 

Protein Synonyms/Alias

 Fructosamine-3-kinase-related protein; FN3K-RP; FN3K-related protein 

Gene Name

 FN3KRP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	DQGRVFVKVNPKAEA	ubiquitination	[1]
45	VFVKVNPKAEARRMF	ubiquitination	[2, 3]
64	ASLTAILKTNTVKVP	ubiquitination	[4]
69	ILKTNTVKVPKPIKV	ubiquitination	[1, 2, 3]
115	ADLHLDNKKLGEMRL	ubiquitination	[1, 4]
123	KLGEMRLKEAGTVGR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation. 

Sequence Annotation

 MOD_RES 20 20 Phosphoserine.  

Keyword

 Complete proteome; Kinase; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0016301; F:kinase activity; IEA:UniProtKB-KW. 

Interpro

 IPR016477; Fructo-/Ketosamine-3-kinase.
 IPR011009; Kinase-like_dom. 

Pfam

 PF03881; Fructosamin_kin 

SMART

  

PROSITE

  

PRINTS