Tag | Content |
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CPLM ID | CPLM-019878 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ADP-ribosylation factor GTPase-activating protein 2 |
Protein Synonyms/Alias | ARF GAP 2; GTPase-activating protein ZNF289; Zinc finger protein 289 |
Gene Name | Arfgap2 |
Gene Synonyms/Alias | Zfp289; Znf289 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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370 | TFASGPPKYKDNPFS | ubiquitination | [1] | 372 | ASGPPKYKDNPFSLG | ubiquitination | [1] | 442 | RQKFAGAKAISSDMF | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi- derived membranes to allow fusion with target membranes (By similarity). |
Sequence Annotation | DOMAIN 11 127 Arf-GAP. ZN_FING 26 49 C4-type. REGION 97 520 Required for interaction with coatomer MOD_RES 145 145 Phosphoserine. MOD_RES 336 336 Phosphoserine. MOD_RES 431 431 Phosphoserine (By similarity). MOD_RES 432 432 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus; GTPase activation; Membrane; Metal-binding; Phosphoprotein; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 520 AA |
Protein Sequence | MAASPSKTEI QTIFKRLRAI PTNKACFDCG AKSPSWASIT YGVFLCIDCS GVHRSLGVHL 60 SFIRSTELDS NWSWLQLRCM QVGGNANATA FFRQHGCMAN DANTKYTSRA AQMYREKIRQ 120 LGSAALTRHG TDLWIDSMNS APSHSPEKKD SDFFTEHTQA PAWDTAATDP SGTQQPALPS 180 ESSSLAQPEQ GPNTDLLGTS PQASLESMYL SAKGPSCTRE LKSSIIGKKK PAAAKKGLGA 240 KKGLGAQKVS NQSFTEIERQ AQVAEKLREQ QAADAKKQAE ESMVASMRLA YQELQIDRKK 300 EEKKLQNLEG KKREQAERLG MGLVSRSSIS HSVLSEMQMI EQETPLSAKS SRSQLDLFDD 360 VGTFASGPPK YKDNPFSLGE TFGSRWDSDA AWGMDRVEEK EPEVTISSIR PISERTASRR 420 EVETRSSGLE SSEARQKFAG AKAISSDMFF GREVDSEYEA RSRLQQLSGS SAISSSDLFG 480 NMDGAHGGGT VSLGNVLPTA DIAQFKQGVK SVAGKMAVLA NGVMNSLQDR YGSY 534 |
Gene Ontology | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005730; C:nucleolus; IEA:Compara. GO:0008060; F:ARF GTPase activator activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |