CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011128
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable metalloprotease ARX1 
Protein Synonyms/Alias
 Associated with ribosomal export complex protein 1 
Gene Name
 ARX1 
Gene Synonyms/Alias
 YDR101C; YD8557.10c 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
27LQESVLNKYRTAGQIacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm. 
Sequence Annotation
  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Nucleus; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 593 AA 
Protein Sequence
MALAISHEDT QILLKDKNIL QESVLNKYRT AGQIAQTALK YVTSLINDSY HSKTTQRQLT 60
VPELCLLTDS FILTRLEQYY KNKVNERGIA IPTTIDIDQI SGGWCPEIDD TQNLLNWNKG 120
KDSTFASSVT GTLRPGDLVK ITLGVHIDGY TSEVSHTMVI YPVDETKPIL QPTGPLLGGK 180
ADAVAAAHIA METVVALLAC ALTPEKLPAS LGGTSSGITG QLIRTIVDTI ARSYNCGVVP 240
GSRVRRIRRF LAGQNEGIVA EREYKGVVWT ESHQEADLLS NTDAKDLTVV DRGQSTPFTN 300
VSAIPSDDFV VQSGEVYLID LKMASLEHCT KKGLVTLETV DSYTGKSHKA GELIARPGAY 360
VRDFAQTHIL KLKTSRQLLT KIDKQGVYPF KLSHLSSNFP FVHENEEELQ SLKKDLKSFR 420
LGMSEISNNY LCVESPIQIA RWVPWDHILK ATNPNGNLSY DATSTLTLPG HELPLPKLGV 480
SAIKLKSLMN STKESISLPV ARECNTIVLC DSSVSTTDRP ELLRLTGGSK TCQPSWIHSQ 540
HELNPQDSIV QGIFQLATLA KDKRFGLLLK ETQPMKQKSV ETSNGGVEET MKM 593 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005654; C:nucleoplasm; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0000055; P:ribosomal large subunit export from nucleus; IMP:SGD. 
Interpro
 IPR000994; Pept_M24_structural-domain. 
Pfam
 PF00557; Peptidase_M24 
SMART
  
PROSITE
  
PRINTS