CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038046
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Active breakpoint cluster region-related protein 
Protein Synonyms/Alias
  
Gene Name
 Abr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
146KAFVDNYKVALETAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 813 AA 
Protein Sequence
MPYIDESPTM SPQLSARSQG GGDSVSPTPP EGLAPGVEAG KGLEMRKLVL SGFLASEEIY 60
INQLEALLLP MKPLKATATT SQPVLTIQQI ETIFYKIQDI YEIHKEFYDN LCPKVQQWDS 120
QVTMGHLFQK LASQLGVYKA FVDNYKVALE TAEKCSQSNN QFQKISEELK VKGPKDSKDS 180
HTSVTMEALL YKPIDRVTRS TLVLHDLLKH TPVDHPDYPL LQDALRISQN FLSSINEDID 240
PRRTAVTTPK GETRQLVKDG FLVEMSESSR KLRHVFLFTD VLLCAKLKKT SAGKHQQYDC 300
KWYIPLADLV FPSPEESEAS PQVHPFPDHE LEDMKTKISA LKSEIQKEKA NKGQSRAIER 360
LKKKMFENEF LLLLNSPTIP FRIHNRNGKS YLFLLSSDYE RSEWREAIQK LQKKDLQAFV 420
LSSVELQVLT GSCFKLRTVH NIPVTSNKDD DESPGLYGFL HVIVHSAKGF KQSANLYCTL 480
EVDSFGYFVS KAKTRVFRDT TEPKWDEEFE IELEGSQSLR ILCYEKCYDK TKVNKDNNEI 540
VDKIMGKGQI QLDPQTVESK NWHTDVIEMN GIKVEFSMKF TSRDMSLKRT PSKKQTGVFG 600
VKISVVTKRE RSKVPYIVRQ CIEEVEKRGI EEVGIYRISG VATDIQALKA VFDANNKDIL 660
LMLSDMDINA IAGTLKLYFR ELPEPLLTDR LYPAFMEGIA LSDPAAKENC MMHLLRSLPD 720
PNLITFLFLL EHLKRVAEKE PINKMSLHNL ATVFGPTLLR PSEVESKAHL TSAADIWSHD 780
VMAQVQVLLY YLQHPPISFA ELKRNTLYFS TDV 813 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030675; F:Rac GTPase activator activity; IDA:MGI.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IGI:MGI.
 GO:0007420; P:brain development; IGI:MGI.
 GO:0042472; P:inner ear morphogenesis; IGI:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0030336; P:negative regulation of cell migration; IGI:MGI.
 GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
 GO:0043314; P:negative regulation of neutrophil degranulation; IGI:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.
 GO:0050766; P:positive regulation of phagocytosis; IGI:MGI.
 GO:0032496; P:response to lipopolysaccharide; IMP:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00168; C2
 PF00169; PH
 PF00620; RhoGAP
 PF00621; RhoGEF 
SMART
 SM00239; C2
 SM00233; PH
 SM00324; RhoGAP
 SM00325; RhoGEF 
PROSITE
 PS50004; C2
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS