CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041223
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myotubularin-related protein 12 
Protein Synonyms/Alias
  
Gene Name
 Mtmr12 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
135PLFGQLKKYPEKLVIubiquitination[1]
139QLKKYPEKLVIHCKDacetylation[2]
139QLKKYPEKLVIHCKDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MLGKGGVGGG GGTKAPKPSF VSYVRPEEIH TDEKEVTEKE VTLHLLPGEQ LLCEASTVLK 60
YVQEDSCQRG VYGRLVCTDF KISFLGDEDS ALDNGGEAQF KNKIIGVNDV PLHCVDQIYG 120
VFDEKKKPLF GQLKKYPEKL VIHCKDLRVL HFCLRYTKEE EVKRIVSGII HHTQSPKLLK 180
RLFLFSYAAA VHGTATDSRN CTVMFDTPKD WCWELERTKG SVKYRTVSVN EGYRVSDRLP 240
AYFVVPTPLP EDDVRRFQGH GIPIWCWSCH NGSALLKMSA LPKEQDDGAL QVQKSFLDGI 300
YKTIHRPPYE MVKTEDLSSN FLSLQEIQSA YCKFKQLFLI DNSSEFWDTD IKWFSLLESS 360
SWLDIIRRCL KKAIEITECL EAQNVNVLLL EENASDLCCL LSSLVQVMMD AHCRTRTGFQ 420
SLIQKEWVMG GHSFLDRCNH LHQSDKEEVP IFLLFLDCVW QLVHQYPPAF EFTETYLTVL 480
SDSLYIPIFS TFFFNSPHQK DTNMGKPGCT KQAFDSAHRV GLVSTV 526 
Gene Ontology
 GO:0016791; F:phosphatase activity; IEA:InterPro. 
Interpro
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom. 
Pfam
  
SMART
  
PROSITE
 PS51339; PPASE_MYOTUBULARIN 
PRINTS