CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018598
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Polypyrimidine tract-binding protein 2 
Protein Synonyms/Alias
 Brain-enriched polypyrimidine tract-binding protein; Brain-enriched PTB; Neural polypyrimidine tract-binding protein; RRM-type RNA-binding protein brPTB 
Gene Name
 Ptbp2 
Gene Synonyms/Alias
 Brptb; Nptb 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
483ANTGGTVKAFKFFQRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre- mRNA splicing, plays also a role in the regulation of translation. 
Sequence Annotation
 DOMAIN 59 133 RRM 1.
 DOMAIN 181 257 RRM 2.
 DOMAIN 338 412 RRM 3.
 DOMAIN 455 529 RRM 4.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 27 27 Phosphoserine.
 MOD_RES 308 308 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSGMVVTAN GNDSKKFKGE DKMDGAPSRV 60
LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH 120
LRNQPIYIQY SNHKELKTDN TLNQRAQVVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV 180
LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG 240
QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL 300
LAVPGALSPL AIPNAAAAAA AAAAGRVGMP GVSAGGNTVL LVSNLNEEMV TPQSLFTLFG 360
VYGDVQRVKI LYNKKDSALI QMADGNQSQL AMNHLNGQKM YGKIIRVTLS KHQTVQLPRE 420
GLDDQGLTKD FGNSPLHRFK KPGSKNFQNI FPPSATLHLS NIPPSVAEED LRTLFANTGG 480
TVKAFKFFQR DHKMALLQMA TVEEAIQALI DLHNYNLGEN HHLRVSFSKS TI 532 
Gene Ontology
 GO:0005681; C:spliceosomal complex; IDA:MGI.
 GO:0003729; F:mRNA binding; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006376; P:mRNA splice site selection; IDA:MGI.
 GO:0033119; P:negative regulation of RNA splicing; IEA:Compara.
 GO:2000177; P:regulation of neural precursor cell proliferation; IMP:MGI. 
Interpro
 IPR006536; HnRNP-L_PTB.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
  
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS