UniProt Accession

 MBP_RAT; P02688; Q505J1; Q8R4K6; Q9Z1J4; Q9Z1J5; Q9Z1J6 

Genbank Protein ID

 AJ132895; AJ132896; AJ132897; AJ132898; M25889; K00512; AF439750; BC094522; X72392 

Genbank Nucleotide ID

 CAA10804.1; CAA10805.1; CAA10806.1; CAA10807.1; AAA41575.1; AAL84189.1; AAH94522.1 

Protein Name

 Myelin basic protein 

Protein Synonyms/Alias

 MBP 

Gene Name

 Mbp 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
14	PSQRHGSKYLATAST	acetylation	[1]
64	SGKVPWLKQSRSPLP	acetylation	[1]
85	PGLCHMYKDSHTRTT	acetylation	[1]
100	HYGSLPQKSQRTQDE	acetylation	[1]
100	HYGSLPQKSQRTQDE	ubiquitination	[2]
115	NPVVHFFKNIVTPRT	acetylation	[1]
146	SWGAEGQKPGFGYGG	acetylation	[1]
146	SWGAEGQKPGFGYGG	ubiquitination	[2]
166	KSAHKGFKGAYDAQG	acetylation	[1]
177	DAQGTLSKIFKLGGR	acetylation	[1]
180	GTLSKIFKLGGRDSR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 8 8 Phosphoserine (By similarity).
 MOD_RES 13 13 Phosphoserine (By similarity).
 MOD_RES 26 26 Citrulline (By similarity).
 MOD_RES 32 32 Citrulline (By similarity).
 MOD_RES 36 36 Phosphothreonine (By similarity).
 MOD_RES 41 41 Phosphoserine (By similarity).
 MOD_RES 47 47 Phosphoserine (By similarity).
 MOD_RES 57 57 Phosphoserine (By similarity).
 MOD_RES 94 94 Phosphotyrosine (By similarity).
 MOD_RES 96 96 Phosphoserine (By similarity).
 MOD_RES 119 119 Phosphothreonine.
 MOD_RES 122 122 Phosphothreonine (By similarity).
 MOD_RES 127 127 Deamidated glutamine (By similarity).
 MOD_RES 131 131 Omega-N-methylarginine; alternate.
 MOD_RES 131 131 Symmetric dimethylarginine; alternate.
 MOD_RES 139 139 Phosphoserine (By similarity).
 MOD_RES 146 146 N6-acetyllysine (By similarity).
 MOD_RES 154 154 Citrulline (By similarity).
 MOD_RES 172 172 Deamidated glutamine (By similarity).
 MOD_RES 184 184 Citrulline (By similarity).
 MOD_RES 186 186 Phosphoserine (By similarity).
 MOD_RES 190 190 Phosphoserine; by UHMK1 (By similarity).
 MOD_RES 195 195 Citrulline (By similarity).  

Keyword

 Acetylation; Alternative splicing; Autoimmune encephalomyelitis; Cell membrane; Citrullination; Complete proteome; Direct protein sequencing; Membrane; Methylation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 195 AA 

Protein Sequence

Gene Ontology

 GO:0043218; C:compact myelin; IDA:RGD.
 GO:0033269; C:internode region of axon; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0019911; F:structural constituent of myelin sheath; IMP:RGD.
 GO:0061024; P:membrane organization; IEA:Compara.
 GO:0042552; P:myelination; IMP:RGD.
 GO:0050771; P:negative regulation of axonogenesis; IMP:RGD.
 GO:0009636; P:response to toxic substance; IEA:Compara. 

Interpro

 IPR000548; Myelin_BP. 

Pfam

 PF01669; Myelin_MBP 

SMART

  

PROSITE

 PS00569; MYELIN_MBP 

PRINTS

 PR00212; MYELINMBP.