UniProt Accession

 ICMT_HUMAN; O60725; Q6FHT0 

Genbank Protein ID

 AF064084; CR541671; CR541711; AL031847; CH471130; BC028168 

Genbank Nucleotide ID

 AAC16554.1; CAG46472.1; CAG46512.1; CAI19441.1; EAW71522.1; AAH28168.1 

Protein Name

 Protein-S-isoprenylcysteine O-methyltransferase 

Protein Synonyms/Alias

 Isoprenylcysteine carboxylmethyltransferase; Prenylated protein carboxyl methyltransferase; PPMT; Prenylcysteine carboxyl methyltransferase; pcCMT 

Gene Name

 ICMT 

Gene Synonyms/Alias

 PCCMT 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
278	PTGLPFIKGVKVDL*	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; Membrane; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; TAS:ProtInc.
 GO:0008140; F:cAMP response element binding protein binding; IEA:Compara.
 GO:0003880; F:protein C-terminal carboxyl O-methyltransferase activity; TAS:ProtInc.
 GO:0004671; F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity; IEA:EC.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0006612; P:protein targeting to membrane; TAS:ProtInc.
 GO:0046578; P:regulation of Ras protein signal transduction; IEA:Compara. 

Interpro

 IPR007269; ICMT_MeTrfase.
 IPR025770; PPMT_MeTrfase. 

Pfam

 PF04140; ICMT 

SMART

  

PROSITE

 PS51564; SAM_ICMT 

PRINTS