CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023175
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vang-like protein 2 
Protein Synonyms/Alias
 Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2 
Gene Name
 VANGL2 
Gene Synonyms/Alias
 KIAA1215; STB1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42RDGGRGDKSVTIQAPubiquitination[1]
306AKKVSGFKVYSLGEEubiquitination[1]
379RLQEEEQKNPREVMDubiquitination[1]
507SEEFVDPKSHKFVMRubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Developmental protein; Disease mutation; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
MDTESQYSGY SYKSGHSRSS RKHRDRRDRH RSKSRDGGRG DKSVTIQAPG EPLLDNESTR 60
GDERDDNWGE TTTVVTGTSE HSISHDDLTR IAKDMEDSVP LDCSRHLGVA AGATLALLSF 120
LTPLAFLLLP PLLWREELEP CGTACEGLFI SVAFKLLILL LGSWALFFRR PKASLPRVFV 180
LRALLMVLVF LLVVSYWLFY GVRILDARER SYQGVVQFAV SLVDALLFVH YLAVVLLELR 240
QLQPQFTLKV VRSTDGASRF YNVGHLSIQR VAVWILEKYY HDFPVYNPAL LNLPKSVLAK 300
KVSGFKVYSL GEENSTNNST GQSRAVIAAA ARRRDNSHNE YYYEEAEHER RVRKRRARLV 360
VAVEEAFTHI KRLQEEEQKN PREVMDPREA AQAIFASMAR AMQKYLRTTK QQPYHTMESI 420
LQHLEFCITH DMTPKAFLER YLAAGPTIQY HKERWLAKQW TLVSEEPVTN GLKDGIVFLL 480
KRQDFSLVVS TKKVPFFKLS EEFVDPKSHK FVMRLQSETS V 521 
Gene Ontology
 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0060187; C:cell pole; IEA:Compara.
 GO:0005911; C:cell-cell junction; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016328; C:lateral plasma membrane; ISS:UniProtKB.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0045176; P:apical protein localization; ISS:UniProtKB.
 GO:0035787; P:cell migration involved in kidney development; ISS:UniProtKB.
 GO:0090103; P:cochlea morphogenesis; IEA:Compara.
 GO:0060028; P:convergent extension involved in axis elongation; IEA:Compara.
 GO:0022007; P:convergent extension involved in neural plate elongation; IEA:Compara.
 GO:0048546; P:digestive tract morphogenesis; IEA:Compara.
 GO:0048105; P:establishment of body hair planar orientation; IEA:Compara.
 GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.
 GO:0090177; P:establishment of planar polarity involved in neural tube closure; IEA:Compara.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0001942; P:hair follicle development; IEA:Compara.
 GO:0001947; P:heart looping; ISS:UniProtKB.
 GO:0060122; P:inner ear receptor stereocilium organization; IEA:Compara.
 GO:0060490; P:lateral sprouting involved in lung morphogenesis; IEA:Compara.
 GO:0003149; P:membranous septum morphogenesis; IEA:Compara.
 GO:0003150; P:muscular septum morphogenesis; IEA:Compara.
 GO:0001843; P:neural tube closure; ISS:UniProtKB.
 GO:0035058; P:nonmotile primary cilium assembly; ISS:UniProtKB.
 GO:0060488; P:orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis; IEA:Compara.
 GO:0003402; P:planar cell polarity pathway involved in axis elongation; IEA:Compara.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Compara.
 GO:0060489; P:planar dichotomous subdivision of terminal units involved in lung branching morphogenesis; IEA:Compara.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Compara.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara.
 GO:0048103; P:somatic stem cell division; IEA:Compara.
 GO:0035019; P:somatic stem cell maintenance; IEA:Compara.
 GO:0042060; P:wound healing; IEA:Compara. 
Interpro
 IPR009539; Strabismus. 
Pfam
 PF06638; Strabismus 
SMART
  
PROSITE
  
PRINTS