UniProt Accession

 LYPL1_HUMAN; Q5VWZ2; A8K677; Q5VWZ3; Q7Z4A3; Q96AV0 

Genbank Protein ID

 AY341430; AK291542; AL360093; AL360093; BC016711 

Genbank Nucleotide ID

 AAQ17077.1; BAF84231.1; CAH70459.1; CAH70460.1; AAH16711.1 

Protein Name

 Lysophospholipase-like protein 1 

Protein Synonyms/Alias

  

Gene Name

 LYPLAL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	DLTFQHIKIIYPTAP	ubiquitination	[1, 2]
70	PRSYTPMKGGISNVW	ubiquitination	[1, 2, 3]
228	LKLWILTKLPGEMEK	ubiquitination	[1, 2, 3, 4]
235	KLPGEMEKQK*****	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. 

Sequence Annotation

 ACT_SITE 124 124 Charge relay system (By similarity).
 ACT_SITE 179 179 Charge relay system (By similarity).
 ACT_SITE 211 211 Charge relay system (By similarity).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004622; F:lysophospholipase activity; NAS:UniProtKB. 

Interpro

 IPR003140; PLipase/COase/thioEstase. 

Pfam

 PF02230; Abhydrolase_2 

SMART

  

PROSITE

  

PRINTS