CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029493
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-2 
Protein Synonyms/Alias
 cDNA FLJ53252, highly similar to Cadherin-2 
Gene Name
 CDH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
417DGLVTVVKPIDFETNubiquitination[1, 2]
505QQNIRYTKLSDPANWubiquitination[1]
725RDKERQAKQLLIDPEubiquitination[2, 3, 4]
741DVRDNILKYDEEGGGubiquitination[2]
771TVEPDAIKPVGIRRMubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Cadherins are calcium dependent cell adhesion proteins (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Cell adhesion; Cell membrane; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 875 AA 
Protein Sequence
MFLLRRYVCI FTEKLKNQAE LYVFLSVKFS NCNGKRKVQY ESSEPADFKV DEDGMVYAVR 60
SFPLSSEHAK FLIYAQDKET QEKWQVAVKL SLKPTLTEES VKESAEVEEI VFPRQFSKHS 120
GHLQRQKRDW VIPPINLPEN SRGPFPQELV RIRSDRDKNL SLRYSVTGPG ADQPPTGIFI 180
INPISGQLSV TKPLDREQIA RFHLRAHAVD INGNQVENPI DIVINVIDMN DNRPEFLHQV 240
WNGTVPEGSK PGTYVMTVTA IDADDPNALN GMLRYRIVSQ APSTPSPNMF TINNETGDII 300
TVAAGLDREK VQQYTLIIQA TDMEGNPTYG LSNTATAVIT VTDVNDNPPE FTAMTFYGEV 360
PENRVDIIVA NLTVTDKDQP HTPAWNAVYR ISGGDPTGRF AIQTDPNSND GLVTVVKPID 420
FETNRMFVLT VAAENQVPLA KGIQHPPQST ATVSVTVIDV NENPYFAPNP KIIRQEEGLH 480
AGTMLTTFTA QDPDRYMQQN IRYTKLSDPA NWLKIDPVNG QITTIAVLDR ESPNVKNNIY 540
NATFLASDNG IPPMSGTGTL QIYLLDINDN APQVLPQEAE TCETPDPNSI NITALDYDID 600
PNAGPFAFDL PLSPVTIKRN WTITRLNGDF AQLNLKIKFL EAGIYEVPII ITDSGNPPKS 660
NISILRVKVC QCDSNGDCTD VDRIVGAGLG TGAIIAILLC IIILLILVLM FVVWMKRRDK 720
ERQAKQLLID PEDDVRDNIL KYDEEGGGEE DQDYDLSQLQ QPDTVEPDAI KPVGIRRMDE 780
RPIHAEPQYP VRSAAPHPGD IGDFINEGLK AADNDPTAPP YDSLLVFDYE GSGSTAGSLS 840
SLNSSSSGGE QDYDYLNDWG PRFKKLADMY GGGDD 875 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR009124; Cadherin/Desmocollin.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.
 PR01820; DESMOCOLLIN.