CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031385
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ57661, highly similar to GMP synthase (glutamine-hydrolyzing) (EC 6.3.5.2) 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66DKVADGFKVVARSGNubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 594 AA 
Protein Sequence
MALCNGDSKM MNKVFGGTVH KKSVREDGVF NISVDNTCSL FRGLQKEEVV LLTHGDSVDK 60
VADGFKVVAR SGNIVAGIAN ESKKLYGAQF HPEVGLTENG KVILKNFLYD IAGCSGTFTV 120
QNRELECIRE IKERVGTSKV LVLLSGGVDS TVCTALLNRA LDQEQVIAVH IDNGFMRKRE 180
SQSVEEALKK LGIQVKVINA AHSFYNGTTT LPISDEDRTP RKRISKTLNM TTSPEEKRKI 240
IGDTFVKIAN EVIGEMNLKP EEVFLAQGTL RPDLIESASL VASGKAELIK THHNDTELIR 300
KLREEGKVIE PLKDFHKDEV RILGRELGLP EELVSRHPFP GPGLAIRVIC AEEPYICKDF 360
PETNNILKIV ADFSASVKKP HTLLQRVKAC TTEEDQEKLM QITSLHSLNA FLLPIKTVGV 420
QGDCRSYSYV CGISSKDEPD WESLIFLARL IPRMCHNVNR VVYIFGPPVK EPPTDVTPTF 480
LTTGVLSTLR QADFEAHNIL RESGYAGKIS QMPVILTPLH FDRDPLQKQP SCQRSVVIRT 540
FITSDFMTGI PATPGNEIPV EVVLKMVTEI KKIPGISRIM YDLTSKPPGT TEWE 594 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003922; F:GMP synthase (glutamine-hydrolyzing) activity; IEA:InterPro.
 GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
 GO:0006177; P:GMP biosynthetic process; IEA:InterPro. 
Interpro
 IPR017926; GATASE.
 IPR001674; GMP_synth_C.
 IPR025777; GMPS_ATP_PPase_dom.
 IPR022310; NAD/GMP_synthase.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF00117; GATase
 PF00958; GMP_synt_C
 PF02540; NAD_synthase 
SMART
  
PROSITE
 PS51273; GATASE_TYPE_1
 PS51553; GMPS_ATP_PPASE 
PRINTS