UniProt Accession

 S10A2_HUMAN; P29034; O00266; Q3KRB9; Q5RHS8; Q9BU83 

Genbank Protein ID

 M87068; Y07755; BX470102; BC002829; BC105787 

Genbank Nucleotide ID

 CAA69033.1; CAI14756.1; AAH02829.3; AAI05788.1 

Protein Name

 Protein S100-A2 

Protein Synonyms/Alias

 CAN19; Protein S-100L; S100 calcium-binding protein A2 

Gene Name

 S100A2 

Gene Synonyms/Alias

 S100L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	YSCQEGDKFKLSKGE	acetylation	[1]
41	EMKELLHKELPSFVG	acetylation	[1]
41	EMKELLHKELPSFVG	ubiquitination	[2]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May act as a modulator against excess calcium accumulation in normal human mammary epithelial cells. May also play a role in suppressing tumor cell growth. 

Sequence Annotation

 DOMAIN 13 48 EF-hand 1.
 DOMAIN 51 86 EF-hand 2.  

Keyword

 3D-structure; Calcium; Complete proteome; Direct protein sequencing; Metal-binding; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 98 AA 

Protein Sequence

Gene Ontology

 GO:0005509; F:calcium ion binding; NAS:UniProtKB.
 GO:0043542; P:endothelial cell migration; IMP:UniProtKB. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001751; S100/CaBP-9k_CS.
 IPR013787; S100_Ca-bd_sub. 

Pfam

 PF01023; S_100 

SMART

  

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00303; S100_CABP 

PRINTS