CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028054
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aconitase, isoform B 
Protein Synonyms/Alias
 Aconitase, isoform D; LD24561p; Mitochondrial aconitase 
Gene Name
 Acon 
Gene Synonyms/Alias
 mAc; CG9244; Dmel_CG9244 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
54DVYLPYEKLNKRLEVacetylation[1]
315QRMADYLKSTGRAGIacetylation[1]
328GIASEAQKYQAKILSacetylation[1]
332EAQKYQAKILSADKNacetylation[1]
569VKVAVDPKSTRLQLLacetylation[1]
613SAAGPWLKYRGHLDNacetylation[1]
697GGRAIIVKSFARIHEacetylation[1]
744LKSLAPGKPVDAEIKacetylation[1]
760GDKVERIKLNHTLNDacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 787 AA 
Protein Sequence
MAARLMNAQA QVCRLGKHVA SEATVVRQFH ASCYTASKVA LSKFDSDVYL PYEKLNKRLE 60
VVRGRLNRPL TLSEKVLYSH LDDPANQDIV RGTSYLRLRP DRVAMQDATA QMALLQFISS 120
GLKKVAVPST VHCDHLIEAQ IGGPKDLARA KDLNKEVYDF LASTCAKYGL GFWKPGSGII 180
HQIILENYAF PGLLMIGTDS HTPNGGGLGG LCIGVGGADA VDVMADIPWE LKCPKVIGVN 240
LTGKISGWTS PKDVILKVAD ILTVKGGTGA IIEYHGKGVD SISCTGMATI CNMGAEIGAT 300
TSLFPFNQRM ADYLKSTGRA GIASEAQKYQ AKILSADKNC EYDELIEINL DTLEPHVNGP 360
FTPDLGHPIS KLGENSKKNG YPMDIRVGLI GSCTNSSYED MGRCASIAKD AMSHGLKSKI 420
PFNVTPGSEQ IRATIERDGI SEVFDKFGGT VLANACGPCI GQWDRKDVKK GDKNTIVTSY 480
NRNFTGRNDA NPATHCFVTS PELVTALSIA GRLDFNPLTD ELTGADGKKF KLKAPFGDEL 540
PAKGFDPGQD TYTAPPPSGE NVKVAVDPKS TRLQLLEPFD KWNGQDLTDL TVLIKVKGKC 600
TTDHISAAGP WLKYRGHLDN ISNNMFIGAT NYENNEMNNI KNQRNGSWGG VPDVARDYKA 660
NGIKWVAVGD ENYGEGSSRE HAALEPRHLG GRAIIVKSFA RIHETNLKKQ GLLPLTFANP 720
ADYDKIQPTS KISLLNLKSL APGKPVDAEI KNGDKVERIK LNHTLNDLQI GWFKAGSALN 780
RMKELAQ 787 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005739; C:mitochondrion; IDA:FlyBase.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
 GO:0003994; F:aconitate hydratase activity; ISS:FlyBase.
 GO:0052632; F:citrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC.
 GO:0052633; F:isocitrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC.
 GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. 
Interpro
 IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
 IPR015937; Acoase/IPM_deHydtase.
 IPR001030; Acoase/IPM_deHydtase_lsu_aba.
 IPR015928; Aconitase/3IPM_dehydase_swvl.
 IPR015932; Aconitase/IPMdHydase_lsu_aba_2.
 IPR018136; Aconitase_4Fe-4S_BS.
 IPR006248; Aconitase_mito-like.
 IPR000573; AconitaseA/IPMdHydase_ssu_swvl. 
Pfam
 PF00330; Aconitase
 PF00694; Aconitase_C 
SMART
  
PROSITE
 PS00450; ACONITASE_1
 PS01244; ACONITASE_2 
PRINTS
 PR00415; ACONITASE.