CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041735
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Huntingtin interacting protein 1, isoform CRA_a 
Protein Synonyms/Alias
 Protein Hip1 
Gene Name
 Hip1 
Gene Synonyms/Alias
 rCG_21910 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
155TRMEYHTKNPRFPGNubiquitination[1]
474RYSKLKEKYSELVQNacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1030 AA 
Protein Sequence
MDRMASSMKQ VPNPLPKVLS RRGVGAGMEA AERESFERTQ TVSVNKAINT QEVAVKEKHA 60
RTCILGTHHE KGAQTFWSVV NRLPLSSNAM LCWKFCHVFH KLLRDGHPNV LKDSLRYKNE 120
LSDMSRMWGH LSEGYGQLCS IYLKLLRTRM EYHTKNPRFP GNLQMSDRQL DEAGESDVNN 180
FFQLTVEMFD YLECELNLFQ TVFNSLDMSR SVSVTTAGQC RLAPLIQVIL DCSHLYDYTV 240
KLLFKLHSCL PADTLQGHRD RFMEQFTKLK DLFQRSSNLQ YFKRLIQIPQ LPENPPNFLR 300
ASALSEHISP VVVIPAEVSS PDSEPVLEKD DLMDMDASQQ SLFDNKFDDI FGSSLSSDPF 360
NFNNQNGVNK DEKDHLIERL YREISGLTGQ LDNVKIESQR AMLQLKGRVS ELEAELAEQQ 420
HLGRQATDDC EFLRTELDEL KRQREDTEKA QRSLTEIEKK AQANEQRYSK LKEKYSELVQ 480
NHADLLRKNA EVTKQVSVAR QAQVDLEREK KELADSFART QEQQDVLETL KHELATSRQE 540
LQVLHGNLET SAQSEAKWLT QIAELEKEQG SLATAAAQRE EEFSALRDQL ESTQLKLAGA 600
QDSMCQQIKD QRRILLAGAR KAAELEIQEA LGQLEEPALL ISCAGATDHL LSKVNSVSSC 660
LEQLEKSRSQ YLACPEEISE LLHSITLLGH LTSDTIIQGT ATSLRAPPES ADSLTEACRQ 720
YGRETLAYLS SLEEEGAMEK ADTTAIANCL GKIKTIGEEL LPRGLDIKQE ELGDLVDKEM 780
AATSAAIEAA TTRIEEILSK SRAGDTGVKL EVNERILGSC TSLMQAIKVL VVASKDLQKE 840
IVESGRGTAS PKEFYAKNSR WTEGLISASK AVGWGATIMV DAADLVVQGK GKFEELMVCS 900
HEIAASTAQL VAASKVKANK GSLNLTQLQQ ASRGVNQATA AVVASTISGK SQIEETDSMD 960
FSSMTLTQIK RQEMDSQVRV LELENDLQKE RQKLGELRKK HYELAGVAEG WEEGTEASPS 1020
AVQEAVPDKE 1030 
Gene Ontology
 GO:0030118; C:clathrin coat; TAS:RGD.
 GO:0030136; C:clathrin-coated vesicle; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; TAS:RGD.
 GO:0030276; F:clathrin binding; IDA:RGD.
 GO:0035091; F:phosphatidylinositol binding; IEA:Compara.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0048268; P:clathrin coat assembly; IDA:RGD.
 GO:0006897; P:endocytosis; TAS:RGD.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:Compara. 
Interpro
 IPR011417; ANTH_dom.
 IPR016024; ARM-type_fold.
 IPR008942; ENTH_VHS.
 IPR013809; Epsin-like_N.
 IPR002558; ILWEQ_dom. 
Pfam
 PF07651; ANTH
 PF01608; I_LWEQ 
SMART
 SM00273; ENTH
 SM00307; ILWEQ 
PROSITE
 PS50942; ENTH
 PS50945; I_LWEQ 
PRINTS