CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016067
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family G member 2 
Protein Synonyms/Alias
 Breast cancer resistance protein 1 homolog; CD338 
Gene Name
 Abcg2 
Gene Synonyms/Alias
 Bcrp1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
165ERINTIIKELGLDKVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux (By similarity). 
Sequence Annotation
 DOMAIN 48 285 ABC transporter.
 DOMAIN 389 653 ABC transmembrane type-2.
 NP_BIND 79 86 ATP (Potential).
 CARBOHYD 596 596 N-linked (GlcNAc...) (Potential).
 CARBOHYD 600 600 N-linked (GlcNAc...) (Potential).
 DISULFID 592 610 By similarity.
 DISULFID 603 603 Interchain (By similarity).  
Keyword
 ATP-binding; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
MSSSNDHVLV PMSQRNKNGL PGMSSRGART LAEGDVLSFH HITYRVKVKS GFLVRKTAEK 60
EILSDINGIM KPGLNAILGP TGGGKSSLLD VLAARKDPRG LSGDVLINGA PQPANFKCSS 120
GYVVQDDVVM GTLTVRENLQ FSAALRLPKA MKTHEKNERI NTIIKELGLD KVADSKVGTQ 180
FTRGISGGER KRTSIGMELI TDPSILFLDE PTTGLDSSTA NAVLLLLKRM SKQGRTIIFS 240
IHQPRYSIFK LFDSLTLLAS GKLMFHGPAQ KALEYFASAG YHCEPYNNPA DFFLDVINGD 300
SSAVMLNRGE QDHEANKTEE PSKREKPIIE NLAEFYINST IYGETKAELD QLPVAQKKKG 360
SSAFREPVYV TSFCHQLRWI ARRSFKNLLG NPQASVAQLI VTVILGLIIG ALYFGLKNDP 420
TGMQNRAGVF FFLTTNQCFT SVSAVELFVV EKKLFIHEYI SGYYRVSSYF FGKLVSDLLP 480
MRFLPSVIYT CILYFMLGLK RTVEAFFIMM FTLIMVAYTA SSMALAIAAG QSVVSVATLL 540
MTISFVFMML FSGLLVNLRT IGPWLSWLQY FSIPRYGFTA LQHNEFLGQE FCPGLNVTMN 600
STCVNSYTIC TGNDYLINQG IDLSPWGLWR NHVALACMII IFLTIAYLKL LFLKKYS 657 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; TAS:RGD.
 GO:0015238; F:drug transmembrane transporter activity; IDA:RGD.
 GO:0046983; F:protein dimerization activity; IDA:RGD.
 GO:0008559; F:xenobiotic-transporting ATPase activity; IEA:Compara.
 GO:0046618; P:drug export; IMP:RGD.
 GO:0060136; P:embryonic process involved in female pregnancy; IDA:RGD.
 GO:0051593; P:response to folic acid; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0010039; P:response to iron ion; IEP:RGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013525; ABC_2_trans.
 IPR003439; ABC_transporter-like.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01061; ABC2_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS51012; ABC_TM2
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS