| Tag | Content |
|---|
| CPLM ID | CPLM-013828 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cystine/glutamate transporter |
Protein Synonyms/Alias | Amino acid transport system xc-; Solute carrier family 7 member 11; xCT |
Gene Name | SLC7A11 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
NCBI Taxa ID | 9601 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 12 | PVVSTISKGGYLQGN | ubiquitination | [1] | | 222 | KGQTQNFKDAFSGRD | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate (By similarity). |
Sequence Annotation | MOD_RES 26 26 Phosphoserine (By similarity).
CARBOHYD 314 314 N-linked (GlcNAc...) (Potential). |
Keyword | Amino-acid transport; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 501 AA |
Protein Sequence | MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV SIIIGTIIGA 60
GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL GTTIKKSGGH YTYILEVFGP 120
LPAFVRVWVE LLIIRPAATA VISLAFGRYI LEPFFIQCEI PELAIKLITA VGITVVMVLN 180
SMSVSWSARI QIFLTFCKLT AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY 240
YGMYAYAGWF YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS 300
NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 360
RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI GLAVAGLIYL RYKCPDMHRP 420
FKVPLFIPAL FSFTCLFMVA LSLYSDPFST GIGSVITLTG VPAYYLFIIW DKKPRWFRIM 480
SEKITRTLQI ILEVVPEEDK L 501 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0015171; F:amino acid transmembrane transporter activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |