UniProt Accession

 PXDC2_HUMAN; Q6UX71; Q96E59; Q96PD9; Q96SU9 

Genbank Protein ID

 AF378757; AY358486; AK027529; AL353147; AC067743; AC069549; AL353147; AC067743; AC069549; BC012885 

Genbank Nucleotide ID

 AAL11994.1; AAQ88850.1; BAB55178.1; CAH71083.1; CAH71083.1; CAH71083.1; CAH71084.1; CAH71084.1; CAH71084.1; AAH12885.1 

Protein Name

 Plexin domain-containing protein 2 

Protein Synonyms/Alias

 Tumor endothelial marker 7-related protein 

Gene Name

 PLXDC2 

Gene Synonyms/Alias

 TEM7R; UNQ2514/PRO6003 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
501	PSRWPAMKFRRGSGH	ubiquitination	[1, 2, 3]
520	EVEPVGEKEGFIVSE	ubiquitination	[2, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May play a role in tumor angiogenesis. 

Sequence Annotation

 DOMAIN 327 372 PSI.
 MOD_RES 506 506 Phosphoserine.
 CARBOHYD 103 103 N-linked (GlcNAc...).
 CARBOHYD 160 160 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 529 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR003659; Plexin-like.
 IPR002165; Plexin_repeat. 

Pfam

 PF01437; PSI 

SMART

 SM00423; PSI 

PROSITE

  

PRINTS