CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023841
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosomal protein of 170 kDa protein B 
Protein Synonyms/Alias
 Centrosomal protein 170B; Cep170B 
Gene Name
 CEP170B 
Gene Synonyms/Alias
 FAM68C; KIAA0284 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
289KIKDHITKFSLRQRRubiquitination[1, 2]
Reference
 [1] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
 Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D.
 Proteomics. 2007 Mar;7(6):868-74. [PMID: 17370265]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Plays a role in microtubule organization (By similarity). 
Sequence Annotation
 DOMAIN 23 73 FHA.
 MOD_RES 360 360 Phosphoserine (By similarity).
 MOD_RES 597 597 Phosphoserine.
 MOD_RES 655 655 Phosphoserine.
 MOD_RES 721 721 Phosphoserine.
 MOD_RES 746 746 Phosphoserine.
 MOD_RES 748 748 Phosphoserine.
 MOD_RES 751 751 Phosphoserine.
 MOD_RES 753 753 Phosphoserine.
 MOD_RES 888 888 Phosphoserine (By similarity).
 MOD_RES 972 972 Phosphoserine (By similarity).
 MOD_RES 975 975 Phosphothreonine (By similarity).
 MOD_RES 986 986 Phosphoserine.
 MOD_RES 988 988 Phosphoserine.
 MOD_RES 1135 1135 Phosphoserine.
 MOD_RES 1304 1304 Phosphothreonine.
 MOD_RES 1356 1356 Phosphoserine (By similarity).
 MOD_RES 1545 1545 Phosphoserine.
 MOD_RES 1548 1548 Phosphoserine.
 CROSSLNK 289 289 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Microtubule; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1589 AA 
Protein Sequence
MSATSWFLVS SSGARHRLPR ELIFVGREEC ELMLQSRSVD KQHAVINYDQ DRDEHWVKDL 60
GSLNGTFVND MRIPDQKYVT LKLNDVIRFG YDSNMYVLER VQHRVPEEAL KHEKYTSQLQ 120
VSVKGLAPKR SEALPEHTPY CEASNPRPEK GDRRPGTEAA SYRTPLYGQP SWWGEDDGST 180
LPDAQRQGEP YPERPKGPVQ QDGELHGFRA PAEPQGCSFR REPSYFEIPT KETPQPSQPP 240
EVPAHEMPTK DAEAGGGGAA PVVQSHASFT IEFDDCSPGK MKIKDHITKF SLRQRRPPGK 300
EATPGEMVSA ETKVADWLVQ NDPSLLHRVG PGDDRHSTKS DLPVHTRTLK GHKHEDGTQS 360
DSEDPLAKAA SAAGVPLEAS GEQVRLQRQI KRDPQELLHN QQAFVIEFFD EDTPRKKRSQ 420
SFTHSPSGDP KADKRRGPTP ADRDRPSVPA PVQAGGRSSG PQRAGSLKRE KTEERLGSPS 480
PASRTPARPF GSVGRRSRLA QDFMAQCLRE SSPAARPSPE KVPPVLPAPL TPHGTSPVGP 540
PTPPPAPTDP QLTKARKQEE DDSLSDAGTY TIETEAQDTE VEEARKMIDQ VFGVLESPEL 600
SRASSATFRP VIRGDRDESD DGGVAQRMAL LQEFASRPLG AAPQAEHQGL PVPGSPGGQK 660
WVSRWASLAD SYSDPGLTED GLGRRGGEPE GSLPVRMRRR LPQLPSERAD SPAGPESSRR 720
SGPGPPELDS EQPSRLFGQE ELDPDSLSDA SGSDGGRGPE PGVEPQDSRR RSPQEGPTWS 780
RGRRSPRAPG EPTPASFFIG DQNGDAVLSR KPLAAPGDGE GLGQTAQPSP PARDGVYVSA 840
NGRMVIQLRP GRSPEPDGPA PAFLRQESFT KEPASGPPAP GKPPHISSHP LLQDLAATRA 900
ARMDFHSQDT HLILKETETA LAALEARLLS NSVDAECEGG STPRPPEDAL SGDSDVDTAS 960
TVSLRSGKSG PSPTTPQPLR AQKEMSPSPP AAQDPGGTAL VSAREQSSER QHHPLGPTDM 1020
GRGEPVRRSA IRRGHRPRGS LDWPSEERGP VLAHLPSSDV MASNHETPEA TGAGRLGSRR 1080
KPAAPPPSPA AREEQSRSSA SSQKGPQALT RSNSLSTPRP TRASRLRRAR LGDASDTEAA 1140
DGERGSLGNP EPVGRPAAEQ AKKLSRLDIL AMPRKRAGSF TGTSDPEAAP ARTSFSGRSV 1200
ELCCASRKPT MAEARAVSRK AANTATTTGP RQPFSRARSG SARYTSNTRR RQQGSDYTST 1260
SEEEYGSRHG SPKHTRSHTS TATQTPRAGS SSRARSRAPG PRDTDDDEEE PDPYGFIVQT 1320
AEIAEIARLS QTLVKDVAIL AQEIHDVAGD GDTLGSSEPA HSASLSNMPS TPASTISARE 1380
ELVQRIPEAS LNFQKVPPGS LNSRDFDQNM NDSCEDALAN KTRPRNREEV IFDNLMLNPV 1440
SQLSQAIREN TEHLAEKMKI LFQNTGRAWE DLEARINAEN EVPILKTSNK EISSILKELR 1500
RVQKQLEVIN AIVDPSGSLD LLTGNRSLAS SAQPGLGKGR VAAQSPPSPA SAEALLPALP 1560
LRNFPQRASC GPPSLPDPTF LPDAERFLI 1589 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW. 
Interpro
 IPR000253; FHA_dom.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA 
SMART
 SM00240; FHA 
PROSITE
 PS50006; FHA_DOMAIN 
PRINTS