CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004195
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60S ribosomal protein L27a 
Protein Synonyms/Alias
 L29 
Gene Name
 Rpl27a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
47HHRINFDKYHPGYFGacetylation[1, 2]
55YHPGYFGKVGMRHYHacetylation[3]
94RVNAAKNKTGVAPIIacetylation[4]
94RVNAAKNKTGVAPIIsuccinylation[4]
94RVNAAKNKTGVAPIIubiquitination[5]
110VVRSGYYKVLGKGKLacetylation[3]
125PKQPVIVKAKFFSRRubiquitination[5]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 MOD_RES 39 39 (3S)-3-hydroxyhistidine (By similarity).
 MOD_RES 47 47 N6-acetyllysine (By similarity).
 MOD_RES 55 55 N6-acetyllysine (By similarity).
 MOD_RES 68 68 Phosphoserine (By similarity).
 MOD_RES 110 110 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Hydroxylation; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 148 AA 
Protein Sequence
MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGMHH HRINFDKYHP GYFGKVGMRH 60
YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGVAPI IDVVRSGYYK VLGKGKLPKQ 120
PVIVKAKFFS RRAEEKIKGV GGACVLVA 148 
Gene Ontology
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR001196; Ribosomal_L15_CS.
 IPR021131; Ribosomal_L18e/L15P. 
Pfam
 PF00828; Ribosomal_L18e 
SMART
  
PROSITE
 PS00475; RIBOSOMAL_L15 
PRINTS