CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011585
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calponin-1 
Protein Synonyms/Alias
 Basic calponin; Calponin H1, smooth muscle 
Gene Name
 Cnn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
19YGLSAEVKNKLAQKYacetylation[1]
97NFIKAITKYGVKPHDacetylation[1]
143NKVNVGVKYAEKQERacetylation[1]
156ERRFEPEKLREGRNIacetylation[1]
172GLQMGTNKFASQQGMacetylation[1]
225GMTAPGTKRQIFEPGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. 
Sequence Annotation
 DOMAIN 28 131 CH.
 REPEAT 164 189 Calponin-like 1.
 REPEAT 204 229 Calponin-like 2.
 REPEAT 243 268 Calponin-like 3.
 MOD_RES 170 170 Phosphothreonine; by ROCK2 (By
 MOD_RES 175 175 Phosphoserine; by ROCK2 (By similarity).
 MOD_RES 180 180 Phosphothreonine; by ROCK2 (By
 MOD_RES 184 184 Phosphothreonine; by ROCK2 (By
 MOD_RES 259 259 Phosphothreonine; by ROCK2 (By  
Keyword
 Actin-binding; Calmodulin-binding; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGSNF MDGLKDGIIL 60
CEFINKLQPG SVKKVNESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV 120
QSTLLALASM AKTKGNKVNV GVKYAEKQER RFEPEKLREG RNIIGLQMGT NKFASQQGMT 180
AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT 240
LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LDEPTHNHHP HNYYNSA 297 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:Compara.
 GO:0003779; F:actin binding; IDA:RGD.
 GO:0031032; P:actomyosin structure organization; IEA:InterPro. 
Interpro
 IPR001997; Calponin.
 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin. 
Pfam
 PF00402; Calponin
 PF00307; CH 
SMART
 SM00033; CH 
PROSITE
 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 
PRINTS
 PR00889; CALPONIN.
 PR00888; SM22CALPONIN.