CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008355
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fos-related antigen 2 
Protein Synonyms/Alias
 FRA-2 
Gene Name
 Fosl2 
Gene Synonyms/Alias
 Fra-2; Fra2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
222AVGPVVVKQEPPEEDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts. 
Sequence Annotation
 DOMAIN 124 187 bZIP.
 REGION 126 128 Basic motif (By similarity).
 REGION 129 136 Leucine-zipper (By similarity).
 MOD_RES 120 120 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphoserine (By similarity).
 MOD_RES 230 230 Phosphoserine (By similarity).
 MOD_RES 320 320 Phosphoserine (By similarity).  
Keyword
 Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 326 AA 
Protein Sequence
MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT INAITTSQDL 60
QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP GVIKTIGTTV GRRRRDEQLS 120
PEEEEKRRIR RERNKLAAAK CRNRRRELTE KLQAETEELE EEKSGLQKEI AELQKEKEKL 180
EFMLVAHGPV CKISPEERRS PPTSGLQSLR GTGSAVGPVV VKQEPPEEDS PSSSAGMDKT 240
QRSVIKPISI AGGGFYGEEP LHTPIVVTST PAITPGTSNL VFTYPSVLEQ ESPASPSESC 300
SKAHRRSSSS GDQSSDSLNS PTLLAL 326 
Gene Ontology
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0003690; F:double-stranded DNA binding; IDA:RGD.
 GO:0046982; F:protein heterodimerization activity; IC:RGD.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0007623; P:circadian rhythm; IEP:RGD.
 GO:0001661; P:conditioned taste aversion; IEP:RGD.
 GO:0007565; P:female pregnancy; IEP:RGD.
 GO:0009648; P:photoperiodism; IEP:RGD.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:RGD.
 GO:0051591; P:response to cAMP; IEP:RGD.
 GO:0009409; P:response to cold; IEP:RGD.
 GO:0034097; P:response to cytokine stimulus; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IMP:RGD.
 GO:0001666; P:response to hypoxia; IMP:RGD.
 GO:0009612; P:response to mechanical stimulus; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.
 GO:0032570; P:response to progesterone stimulus; IEP:RGD.
 GO:0009636; P:response to toxic substance; IEP:RGD.
 GO:0030431; P:sleep; IEP:RGD.
 GO:0006366; P:transcription from RNA polymerase II promoter; IMP:RGD. 
Interpro
 IPR004827; bZIP.
 IPR000837; Leuzip_Fos. 
Pfam
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS
 PR00042; LEUZIPPRFOS.