CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006406
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cannabinoid receptor 2 
Protein Synonyms/Alias
 CB-2; CB2; hCB2; CX5 
Gene Name
 CNR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
329RGLGSEAKEEAPRSSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. 
Sequence Annotation
 MOD_RES 335 335 Phosphoserine (By similarity).
 MOD_RES 336 336 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine.
 CARBOHYD 11 11 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Cell membrane; Cell projection; Complete proteome; G-protein coupled receptor; Glycoprotein; Inflammatory response; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 360 AA 
Protein Sequence
MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 60
SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 120
VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 180
ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 240
VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 300
LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC 360 
Gene Ontology
 GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
 GO:0031234; C:extrinsic to internal side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
 GO:0004949; F:cannabinoid receptor activity; TAS:ProtInc.
 GO:0007610; P:behavior; TAS:ProtInc.
 GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0045759; P:negative regulation of action potential; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0033004; P:negative regulation of mast cell activation; IEA:Compara.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara. 
Interpro
 IPR001551; Canbinoid_rcpt_2.
 IPR002230; Cnbnoid_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00523; CANABINOID2R.
 PR00362; CANNABINOIDR.
 PR00237; GPCRRHODOPSN.