| Tag | Content |
|---|
| CPLM ID | CPLM-003658 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase SUV420H1 |
Protein Synonyms/Alias | Suppressor of variegation 4-20 homolog 1; Su(var)4-20 homolog 1; Suv4-20h1 |
Gene Name | Suv420h1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 20 | NGRRNGSKLSNDHQQ | acetylation | [1] | | 31 | DHQQNQSKLQHAGKD | acetylation | [1] | | 37 | SKLQHAGKDALKTGR | acetylation | [1] | | 216 | GAKIVATKEWKRNDK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). |
Sequence Annotation | DOMAIN 193 308 SET. |
Keyword | Chromatin regulator; Chromosome; Complete proteome; Methyltransferase; Nucleus; Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 883 AA |
Protein Sequence | MKWLGDSKNM VVNGRRNGSK LSNDHQQNQS KLQHAGKDAL KTGRNAVERR PNRCHGNSGF 60
EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTSAFPSRSS RHISKADSFS 120
HNNPMRFRPI KGRQEELKEV IERFKKDEHL EKAFKCLTSG EWARHYFLNK NKMQEKLFKE 180
HVFIYLRMFA TDSGFEILPC NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN 240
MLLRHGENDF SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG 300
EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG LRETDKRLNR 360
LKKLGDSSKS SDSQSVSSNT DADTTQEKDN ATSNRKSSVG VKKNSKSRAL TRQSMPRVPA 420
ASNSTSPKLV HMNNSRVPKK LRKPAKPLLS KIKLRNHCKR LDQKSTSRKL EMGNLVLKEP 480
KVVLYKNLPI KKEREAEGPV HAAVGSGCLT RHAAREHRQN PGRGAHSQGD SLPCTYTTRR 540
SLRTRTGLKE TTDIKLAPSP LDGYKNGILE PYPDSGQQPT PEVLEELAPE TALREEASQE 600
CPKSDSCPSR KKFRQGKPVK HLAKTEDCSP EHSFPGKDGL PDLPGPHPDQ GEPSGTVRVP 660
VSYTDSAPSP VGCSIVTPDS FTTKDSFRTA QSKKKRRVTR YDAQLILENS SGIPKLTLRR 720
RHDSSSKTND HESDSVNSSK ISIKLSKDHE SDSNLYVAKL SNGVSSGPGS SSTKLKIQLK 780
RDEESRGPCA EGLHENGVCC SDPLSLLESQ MEVDDYSQYE EDSTDDSSSS EGEEEEEDCE 840
DDFDDDFIPL PPAKRLRLIV GKDSIDIDIS SRRREDQSLR LNA 883 |
Gene Ontology | GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Compara. GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:Compara. GO:0018024; F:histone-lysine N-methyltransferase activity; ISS:UniProtKB. GO:0034773; P:histone H4-K20 trimethylation; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |