UniProt Accession

 CPLX2_RAT; P84087; O09056; Q13329; Q28184; Q64386 

Genbank Protein ID

 U35099; D70816 

Genbank Nucleotide ID

 AAC52271.1; BAA11096.1 

Protein Name

 Complexin-2 

Protein Synonyms/Alias

 Complexin II; CPX II; Synaphin-1 

Gene Name

 Cplx2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
69	VRQQIRDKYGLKKKE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis. 

Sequence Annotation

 REGION 41 97 Interaction with the SNARE complex.
 MOD_RES 93 93 Phosphoserine.  

Keyword

 Cell junction; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Exocytosis; Mast cell degranulation; Neurotransmitter transport; Nucleus; Phosphoprotein; Reference proteome; Synapse; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0070033; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; IDA:RGD.
 GO:0017075; F:syntaxin-1 binding; IDA:MGI.
 GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
 GO:0031915; P:positive regulation of synaptic plasticity; ISS:UniProtKB.
 GO:0016079; P:synaptic vesicle exocytosis; IDA:RGD.
 GO:0006904; P:vesicle docking involved in exocytosis; TAS:ProtInc. 

Interpro

 IPR008849; Synaphin. 

Pfam

 PF05835; Synaphin 

SMART

  

PROSITE

  

PRINTS