CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013498
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 OCIA domain-containing protein 2 
Protein Synonyms/Alias
 Ovarian carcinoma immunoreactive antigen-like protein 
Gene Name
 OCIAD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41IHRAEISKIMRECQEacetylation[1]
41IHRAEISKIMRECQEubiquitination[2, 3, 4]
53CQEESFWKRALPFSLubiquitination[4]
138LLTCEECKIKHGLSEubiquitination[4]
140TCEECKIKHGLSEKGubiquitination[4]
146IKHGLSEKGDSQPSAubiquitination[4]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 DOMAIN 1 120 OCIA.
 MOD_RES 41 41 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Endosome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 154 AA 
Protein Sequence
MASASARGNQ DKDAHFPPPS KQSLLFCPKS KLHIHRAEIS KIMRECQEES FWKRALPFSL 60
VSMLVTQGLV YQGYLAANSR FGSLPKVALA GLLGFGLGKV SYIGVCQSKF HFFEDQLRGA 120
GFGPQHNRHC LLTCEECKIK HGLSEKGDSQ PSAS 154 
Gene Ontology
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara. 
Interpro
 IPR009764; OCIA. 
Pfam
 PF07051; OCIA 
SMART
  
PROSITE
  
PRINTS