CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028907
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mib1 protein 
Protein Synonyms/Alias
  
Gene Name
 Mib1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28GPDWKWGKQDGGEGHubiquitination[1]
222LKCVQDAKGGSFYRDubiquitination[1]
421RLSQLLKKLFETQESubiquitination[1]
485DILKLLLKQNVDVEAubiquitination[1]
726QDMQDVGKVDAAWEPubiquitination[1]
936GNIPVLQKDKDNTNVubiquitination[1]
949NVNADVQKLQQQLQDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Metal-binding; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1006 AA 
Protein Sequence
MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV VWDNGTAANY 60
RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC AECTNYDLCT VCYHGDKHHL 120
RHRFYRITTP GSERVLLESR RKSKKITARG IFAGARVVRG VDWQWEDQDG GNGRRGKVTE 180
IQDWSASSPH SAAYVLWDNG AKNLYRVGFE GMSDLKCVQD AKGGSFYRDH CPVLGEQNGN 240
RNPGGLQIGD LVNIDLDLEI VQSLQHGHGG WTDGMFETLT TTGTVCGIDE DHDIVVQYPS 300
GNRWTFNPAV LTKANIVRSG DAAQGAEGGT SQFQVGDLVQ VCYDLERIKL LQRGHGEWAE 360
AMLPTLGKVG RVQQIYSDSD LKVEVCGTSW TYNPAAVSKV APAGSAISNA SGERLSQLLK 420
KLFETQESGD LNEELVKAAA NGDVAKVEDL LKRPDVDVNG QCAGHTAMQA ASQNGHVDIL 480
KLLLKQNVDV EAEDKDGDRA VHHAAFGDEG AVIEVLHRGS ADLNARNKRR QTPLHIAVNK 540
GHLQVVKTLL DFGCHPSLQD SEGDTPLHDA ISKKRDDILA VLLEAGADVT ITNNNGFNAL 600
HHAALRGNPS AMRVLLSKLP RPWIVDEKKD DGYTALHLAA LNNHVEVAEL LVHQGNANLD 660
IQNVNQQTAL HLAVERQHTQ IVRLLVRAGA KLDIQDKDGD TPLHEALRHH TLSQLRQLQD 720
MQDVGKVDAA WEPSKNTLIM GLGTQGAEKK SAASIACFLA ANGADLSIRN KKGQSPLDLC 780
PDPSLCKALA KCHKEKVSGK VGSRSPSMIS NDSETLEECM VCSDMKRDTL FGPCGHIATC 840
SLCSPRVKKC LICKEQVQSR TKIEECVVCS DKKAAVLFQP CGHMCACENC ASLMKKCVQC 900
RAVVERRVPF ITCCGGKSSE DPSDEISSGN IPVLQKDKDN TNVNADVQKL QQQLQDIKEQ 960
TMCPVCLDRL KNMIFLCGHG TCQLCGDRMS ECPICRKAIE RRILLY 1006 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001568; P:blood vessel development; IMP:MGI.
 GO:0001947; P:heart looping; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
 GO:0001841; P:neural tube formation; IMP:MGI.
 GO:0007219; P:Notch signaling pathway; IMP:MGI.
 GO:0045807; P:positive regulation of endocytosis; IDA:MGI.
 GO:0001756; P:somitogenesis; IMP:MGI. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR010606; Mib_Herc2.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR000433; Znf_ZZ. 
Pfam
 PF00023; Ank
 PF12796; Ank_2
 PF06701; MIB_HERC2
 PF00569; ZZ 
SMART
 SM00248; ANK
 SM00184; RING
 SM00291; ZnF_ZZ 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS51416; MIB_HERC2
 PS50089; ZF_RING_2
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS
 PR01415; ANKYRIN.