CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005984
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional regulatory protein DEP1 
Protein Synonyms/Alias
  
Gene Name
 DEP1 
Gene Synonyms/Alias
 FUN54; YAL013W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
69LANLPELKYAPKLSSacetylation[1]
73PELKYAPKLSSLVKQacetylation[1]
79PKLSSLVKQETLTESacetylation[1]
355YRANPVDKLEVIVDRacetylation[1]
377SDLEGLRKYFHSFPGacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. 
Sequence Annotation
 MOD_RES 56 56 Phosphoserine.
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 370 370 Phosphoserine.  
Keyword
 Chromatin regulator; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 405 AA 
Protein Sequence
MSQQTPQESE QTTAKEQDLD QESVLSNIDF NTDLNHNLNL SEYCISSDAG TEKMDSDEEK 60
SLANLPELKY APKLSSLVKQ ETLTESLKRP HEDEKEAIDE AKKMKVPGEN EDESKEEEKS 120
QELEEAIDSK EKSTDARDEQ GDEGDNEEEN NEEDNENENE HTAPPALVMP SPIEMEEQRM 180
TALKEITDIE YKFAQLRQKL YDNQLVRLQT ELQMCLEGSH PELQVYYSKI AAIRDYKLHR 240
AYQRQKYELS CINTETIATR TFIHQDFHKK VTDLRARLLN RTTQTWYDIN KERRDMDIVI 300
PDVNYHVPIK LDNKTLSCIT GYASAAQLCY PGEPVAEDLA CESIEYRYRA NPVDKLEVIV 360
DRMRLNNEIS DLEGLRKYFH SFPGAPELNP LRDSEINDDF HQWAQ 405 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0033698; C:Rpd3L complex; IDA:SGD.
 GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.
 GO:0016575; P:histone deacetylation; IMP:SGD.
 GO:0061188; P:negative regulation of chromatin silencing at rDNA; IMP:SGD.
 GO:0061186; P:negative regulation of chromatin silencing at silent mating-type cassette; IMP:SGD.
 GO:0031939; P:negative regulation of chromatin silencing at telomere; IDA:SGD.
 GO:1900471; P:negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:1900473; P:negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:1900526; P:negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:1900375; P:positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:1900472; P:positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:1900525; P:positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0061408; P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress; IMP:SGD.
 GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR013907; Sds3. 
Pfam
 PF08598; Sds3 
SMART
  
PROSITE
  
PRINTS