UniProt Accession

 RFTN1_HUMAN; Q14699; Q0D2G0; Q496Y2; Q4QQI7; Q5JB48; Q7Z7P2 

Genbank Protein ID

 AY237654; D42043; BC051336; BC069209; BC098270; BC100667; BC100669; BC121795 

Genbank Nucleotide ID

 AAO91814.1; BAA07644.1; AAH51336.1; AAH69209.1; AAH98270.2; AAI00668.2; AAI00670.2; AAI21796.1 

Protein Name

 Raftlin 

Protein Synonyms/Alias

 Cell migration-inducing gene 2 protein; Raft-linking protein 

Gene Name

 RFTN1 

Gene Synonyms/Alias

 KIAA0084; MIG2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
147	LIPEFIKKIQEAASQ	ubiquitination	[1, 2]
235	RGEVPLAKQPSSPSG	ubiquitination	[2]
276	HEEPLSGKMEIFTLF	ubiquitination	[2]
285	EIFTLFNKPKSHQKC	ubiquitination	[1]
424	SEGSVSTKQIVFLQR	ubiquitination	[3]
479	QQAEENEKNLEDQSS	ubiquitination	[2]
487	NLEDQSSKAGDMGNC	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor- mediated signaling. 

Sequence Annotation

 MOD_RES 183 183 Phosphoserine (By similarity).
 MOD_RES 220 220 Phosphoserine.
 MOD_RES 555 555 Phosphoserine (By similarity).
 LIPID 2 2 N-myristoyl glycine.
 LIPID 3 3 S-palmitoyl cysteine (Probable).  

Keyword

 Cell membrane; Complete proteome; Lipoprotein; Membrane; Myristate; Palmitate; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 578 AA 

Protein Sequence

Gene Ontology

 GO:0045121; C:membrane raft; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS