UniProt Accession

 MEF2C_HUMAN; Q06413; C9JMZ0; D7F7N5; F8W7V7 

Genbank Protein ID

 L08895; S57212; FM163484; AL833268; AL833274; AC008525; AC008835 

Genbank Nucleotide ID

 AAA59578.1; AAB25838.1; CAQ57795.2 

Protein Name

 Myocyte-specific enhancer factor 2C 

Protein Synonyms/Alias

  

Gene Name

 MEF2C 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	HSPESEDKYRKINED	acetylation	[1]
119	ESEDKYRKINEDIDL	acetylation	[1]
234	VSPGNLNKNMQAKSP	acetylation	[1]
239	LNKNMQAKSPPPMNL	acetylation	[1]
252	NLGMNNRKPDLRVLI	acetylation	[1]
264	VLIPPGSKNTMPSVS	acetylation	[1]
391	STQSLNIKSEPVSPP	sumoylation	[2, 3]

Reference

 [1] Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation.
 Ma K, Chan JK, Zhu G, Wu Z.
 Mol Cell Biol. 2005 May;25(9):3575-82. [PMID: 15831463]
 [2] Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.
 Grégoire S, Yang XJ.
 Mol Cell Biol. 2005 Mar;25(6):2273-87. [PMID: 15743823]
 [3] Phosphorylation-facilitated sumoylation of MEF2C negatively regulates its transcriptional activity.
 Kang J, Gocke CB, Yu H.
 BMC Biochem. 2006 Feb 14;7:5. [PMID: 16478538] 

Functional Description

 Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. 

Sequence Annotation

 DOMAIN 3 57 MADS-box.
 DNA_BIND 58 86 Mef2-type (Potential).
 REGION 271 278 Beta domain.
 REGION 368 399 Transcription repressor.
 MOD_RES 4 4 N6-acetyllysine.
 MOD_RES 59 59 Phosphoserine; by CK2 (By similarity).
 MOD_RES 116 116 N6-acetyllysine.
 MOD_RES 119 119 N6-acetyllysine.
 MOD_RES 234 234 N6-acetyllysine.
 MOD_RES 239 239 N6-acetyllysine.
 MOD_RES 252 252 N6-acetyllysine.
 MOD_RES 264 264 N6-acetyllysine.
 MOD_RES 293 293 Phosphothreonine; by MAPK14.
 MOD_RES 300 300 Phosphothreonine; by MAPK14.
 MOD_RES 396 396 Phosphoserine; by CDK5.
 MOD_RES 419 419 Phosphoserine; by MAPK7.
 CROSSLNK 391 391 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Activator; Alternative splicing; Apoptosis; Complete proteome; Developmental protein; Differentiation; DNA-binding; Epilepsy; Isopeptide bond; Mental retardation; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 473 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016607; C:nuclear speck; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0003680; F:AT DNA binding; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0035198; F:miRNA binding; IDA:UniProtKB.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB.
 GO:0000983; F:RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0001782; P:B cell homeostasis; ISS:UniProtKB.
 GO:0042100; P:B cell proliferation; ISS:UniProtKB.
 GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.
 GO:0001568; P:blood vessel development; ISS:UniProtKB.
 GO:0001974; P:blood vessel remodeling; ISS:UniProtKB.
 GO:0003211; P:cardiac ventricle formation; ISS:UniProtKB.
 GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.
 GO:0035690; P:cellular response to drug; ISS:UniProtKB.
 GO:0071498; P:cellular response to fluid shear stress; ISS:UniProtKB.
 GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
 GO:0071374; P:cellular response to parathyroid hormone stimulus; IDA:UniProtKB.
 GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:UniProtKB.
 GO:0035984; P:cellular response to trichostatin A; ISS:UniProtKB.
 GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
 GO:0001958; P:endochondral ossification; ISS:UniProtKB.
 GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; ISS:UniProtKB.
 GO:0002467; P:germinal center formation; ISS:UniProtKB.
 GO:0072102; P:glomerulus morphogenesis; ISS:UniProtKB.
 GO:0001947; P:heart looping; ISS:UniProtKB.
 GO:0006959; P:humoral immune response; ISS:UniProtKB.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0007611; P:learning or memory; ISS:UniProtKB.
 GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
 GO:0007521; P:muscle cell fate determination; ISS:UniProtKB.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0014902; P:myotube differentiation; IEP:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0030279; P:negative regulation of ossification; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0072160; P:nephron tubule epithelial cell differentiation; ISS:UniProtKB.
 GO:0014033; P:neural crest cell differentiation; ISS:UniProtKB.
 GO:0048666; P:neuron development; ISS:UniProtKB.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
 GO:0003151; P:outflow tract morphogenesis; ISS:UniProtKB.
 GO:0030220; P:platelet formation; ISS:UniProtKB.
 GO:0010694; P:positive regulation of alkaline phosphatase activity; ISS:UniProtKB.
 GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
 GO:2000987; P:positive regulation of behavioral fear response; ISS:UniProtKB.
 GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
 GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IDA:UniProtKB.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISS:UniProtKB.
 GO:2000111; P:positive regulation of macrophage apoptotic process; ISS:UniProtKB.
 GO:0045663; P:positive regulation of myoblast differentiation; IMP:UniProtKB.
 GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
 GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
 GO:0090073; P:positive regulation of protein homodimerization activity; ISS:UniProtKB.
 GO:2001016; P:positive regulation of skeletal muscle cell differentiation; IDA:UniProtKB.
 GO:0048643; P:positive regulation of skeletal muscle tissue development; IMP:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0003138; P:primary heart field specification; ISS:UniProtKB.
 GO:0002634; P:regulation of germinal center formation; ISS:UniProtKB.
 GO:0045652; P:regulation of megakaryocyte differentiation; ISS:UniProtKB.
 GO:0060025; P:regulation of synaptic activity; ISS:UniProtKB.
 GO:0009615; P:response to virus; IEP:UniProtKB.
 GO:0003139; P:secondary heart field specification; ISS:UniProtKB.
 GO:0003185; P:sinoatrial valve morphogenesis; ISS:UniProtKB.
 GO:0051145; P:smooth muscle cell differentiation; ISS:UniProtKB.
 GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
 GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0055012; P:ventricular cardiac muscle cell differentiation; ISS:UniProtKB. 

Interpro

 IPR022102; HJURP_C.
 IPR002100; TF_MADSbox. 

Pfam

 PF12347; HJURP_C
 PF00319; SRF-TF 

SMART

 SM00432; MADS 

PROSITE

 PS00350; MADS_BOX_1
 PS50066; MADS_BOX_2 

PRINTS

 PR00404; MADSDOMAIN.