CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029979
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Saposin-D 
Protein Synonyms/Alias
  
Gene Name
 PSAP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
290VPAKVASKNVIPALEubiquitination[1]
303LELVEPIKKHEVPAKubiquitination[2]
304ELVEPIKKHEVPAKSubiquitination[1]
344EILDAFDKMCSKLPKubiquitination[1]
413GGFCEVCKKLVGYLDubiquitination[1]
414GFCEVCKKLVGYLDRubiquitination[1]
429NLEKNSTKQEILAALubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 559 AA 
Protein Sequence
MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS 60
LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI 120
IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY 180
PQDGPRSKPQ PKDNGDVCQD CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI 240
CKNYISQYSE IAIQMMMHMQ PKEICALVGF CDEVKEMPMQ TLVPAKVASK NVIPALELVE 300
PIKKHEVPAK SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV 360
VDTYGSSILS ILLEEVSPEL VCSMLHLCSG TRLPALTVHV TQPKDGGFCE VCKKLVGYLD 420
RNLEKNSTKQ EILAALEKGC SFLPDPYQKQ CDQFVAEYEP VLIEILVEVM DPSFVCLKIG 480
ACPSAHKPLL GTEKCIWGPS YWCQNTETAA QCNAVEHCKR HVWIGCWGVG VGSCLWPTWA 540
PTLLSTSGCQ ETASKASRT 559 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005764; C:lysosome; IEA:InterPro.
 GO:0006665; P:sphingolipid metabolic process; IEA:InterPro. 
Interpro
 IPR003119; SapA.
 IPR007856; SapB_1.
 IPR008138; SapB_2.
 IPR008373; Saposin.
 IPR011001; Saposin-like.
 IPR021165; Saposin_chordata.
 IPR008139; SaposinB. 
Pfam
 PF02199; SapA
 PF05184; SapB_1
 PF03489; SapB_2 
SMART
 SM00162; SAPA
 SM00741; SapB 
PROSITE
 PS51110; SAP_A
 PS50015; SAP_B 
PRINTS
 PR01797; SAPOSIN.