CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018928
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homogentisate 1,2-dioxygenase 
Protein Synonyms/Alias
 Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase 
Gene Name
 HGD 
Gene Synonyms/Alias
 HGO 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98DPNQLRWKPFEIPKAacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
  
Sequence Annotation
 METAL 335 335 Iron.
 METAL 341 341 Iron.
 METAL 371 371 Iron.
 MOD_RES 98 98 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Complete proteome; Dioxygenase; Disease mutation; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Polymorphism; Reference proteome; Tyrosine catabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 445 AA 
Protein Sequence
MAELKYISGF GNECSSEDPR CPGSLPEGQN NPQVCPYNLY AEQLSGSAFT CPRSTNKRSW 60
LYRILPSVSH KPFESIDEGQ VTHNWDEVDP DPNQLRWKPF EIPKASQKKV DFVSGLHTLC 120
GAGDIKSNNG LAIHIFLCNT SMENRCFYNS DGDFLIVPQK GNLLIYTEFG KMLVQPNEIC 180
VIQRGMRFSI DVFEETRGYI LEVYGVHFEL PDLGPIGANG LANPRDFLIP IAWYEDRQVP 240
GGYTVINKYQ GKLFAAKQDV SPFNVVAWHG NYTPYKYNLK NFMVINSVAF DHADPSIFTV 300
LTAKSVRPGV AIADFVIFPP RWGVADKTFR PPYYHRNCMS EFMGLIRGHY EAKQGGFLPG 360
GGSLHSTMTP HGPDADCFEK ASKVKLAPER IADGTMAFMF ESSLSLAVTK WGLKASRCLD 420
ENYHKCWEPL KSHFTPNSRN PAEPN 445 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004411; F:homogentisate 1,2-dioxygenase activity; EXP:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006559; P:L-phenylalanine catabolic process; TAS:Reactome.
 GO:0006572; P:tyrosine catabolic process; TAS:ProtInc. 
Interpro
 IPR005708; Homogentis_dOase.
 IPR014710; RmlC-like_jellyroll.
 IPR011051; RmlC_Cupin. 
Pfam
 PF04209; HgmA 
SMART
  
PROSITE
  
PRINTS