CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Piezo-type mechanosensitive ion channel component 2 
Protein Synonyms/Alias
 Protein FAM38B 
Gene Name
 PIEZO2 
Gene Synonyms/Alias
 C18orf30; C18orf58; FAM38B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2173KRELYMEKLQEHLIKubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons (By similarity). 
Sequence Annotation
 CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1013 1013 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1085 1085 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2752 AA 
Protein Sequence
MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT TMQGHTGRLL 60
KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE KTFRQIGFES LKGADAGNGI 120
RVFVPDIGMF IASLTIWLLC RNIVQKPVTD EAAQSNPEFE NEELAEGEKI DSEEALIYEE 180
DFNGGDGVEG ELEESTKLKM FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS 240
LTSSVYFFVF LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP 300
NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT LIRIWLQEPL 360
VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK LLSMTQDDYK PSDGLLVTVN 420
GNPVDYHTIH PSLPMENGPG KADLYSTPQY RWEPSDESSE KREEEEEEKE EFEEERSREE 480
KRSIKVHAMV SVFQFIMKQS YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA 540
MISSPFMVVY GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH 600
LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE EKQERKKVEQ 660
EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF EGKIVMYKII YMVLFLFCVA 720
LYQVHYEWWR KILKYFWMSV VIYTMLVLIF IYTYQFENFP GLWQNMTGLK KEKLEDLGLK 780
QFTVAELFTR IFIPTSFLLV CILHLHYFHD RFLELTDLKS IPSKEDNTIY SHAKVNGRVY 840
LIINSIKKKL PIHQNELAHP EGSLPDLTMM HLTASLEKPE VRKLAEPGEE KLEGYSEKAQ 900
KGDLGKDSEE SEEDGEEEEE SEEEEETSDL RNKWHLVIDR LTVLFLKFLE YFHKLQVFMW 960
WILELHIIKI VSSYIIWVSV KEVSLFNYVF LISWAFALPY AKLRRLASSV CTVWTCVIIV 1020
CKMLYQLQTI KPENFSVNCS LPNENQTNIP FNELNKSLLY SAPIDPTEWV GLRKSSPLLV 1080
YLRNNLLMLA ILAFEVTIYR HQEYYRGRNN LTAPVSRTIF HDITRLHLDD GLINCAKYFI 1140
NYFFYKFGLE TCFLMSVNVI GQRMDFYAMI HACWLIAVLY RRRRKAIAEI WPKYCCFLAC 1200
IITFQYFICI GIPPAPCRDY PWRFKGASFN DNIIKWLYFP DFIVRPNPVF LVYDFMLLLC 1260
ASLQRQIFED ENKAAVRIMA GDNVEICMNL DAASFSQHNP VPDFIHCRSY LDMSKVIIFS 1320
YLFWFVLTII FITGTTRISI FCMGYLVACF YFLLFGGDLL LKPIKSILRY WDWLIAYNVF 1380
VITMKNILSI GACGYIGTLV HNSCWLIQAF SLACTVKGYQ MPAANSPCTL PSGEAGIIWD 1440
SICFAFLLLQ RRVFMSYYFL HVVADIKASQ ILASRGAELF QATIVKAVKA RIEEEKKSMD 1500
QLKRQMDRIK ARQQKYKKGK ERMLSLTQEP GEGQDMQKLS EEDDEREADK QKAKGKKKQW 1560
WRPWVDHASM VRSGDYYLFE TDSEEEEEEE LKKEDEEPPR RSAFQFVYQA WITDPKTALR 1620
QRHKEKKRSA REERKRRRKG SKEGPVEWED REDEPIKKKS DGPDNIIKRI FNILKFTWVL 1680
FLATVDSFTT WLNSISREHI DISTVLRIER CMLTREIKKG NVPTRESIHM YYQNHIMNLS 1740
RESGLDTIDE HPGAASGAQT AHRMDSLDSH DSISSEPTQC TMLYSRQGTT ETIEEVEAEQ 1800
EEEAGSTAPE PREAKEYEAT GYDVGAMGAE EASLTPEEEL TQFSTLDGDV EAPPSYSKAV 1860
SFEHLSFGSQ DDSAGKNRMA VSPDDSRTDK LGSSILPPLT HELTASELLL KKMFHDDELE 1920
ESEKFYVGQP RFLLLFYAMY NTLVARSEMV CYFVIILNHM VSASMITLLL PILIFLWAML 1980
SVPRPSRRFW MMAIVYTEVA IVVKYFFQFG FFPWNKNVEV NKDKPYHPPN IIGVEKKEGY 2040
VLYDLIQLLA LFFHRSILKC HGLWDEDDMT ESGMAREESD DELSLGHGRR DSSDSLKSIN 2100
LAASVESVHV TFPEQQTAVR RKRSGSSSEP SQRSSFSSNR SQRGSTSTRN SSQKGSSVLS 2160
IKQKGKRELY MEKLQEHLIK AKAFTIKKTL EIYVPIKQFF YNLIHPEYSA VTDVYVLMFL 2220
ADTVDFIIIV FGFWAFGKHS AAADITSSLS EDQVPGPFLV MVLIQFGTMV VDRALYLRKT 2280
VLGKVIFQVI LVFGIHFWMF FILPGVTERK FSQNLVAQLW YFVKCVYFGL SAYQIRCGYP 2340
TRVLGNFLTK SYNYVNLFLF QGFRLVPFLT ELRAVMDWVW TDTTLSLSSW ICVEDIYAHI 2400
FILKCWRESE KRYPQPRGQK KKKVVKYGMG GMIIVLLICI VWFPLLFMSL IKSVAGVINQ 2460
PLDVSVTITL GGYQPIFTMS AQQSQLKVMD QQSFNKFIQA FSRDTGAMQF LENYEKEDIT 2520
VAELEGNSNS LWTISPPSKQ KMIHELLDPN SSFSVVFSWS IQRNLSLGAK SEIATDKLSF 2580
PLKNITRKNI AKMIAGNSTE SSKTPVTIEK IYPYYVKAPS DSNSKPIKQL LSENNFMDIT 2640
IILSRDNTTK YNSEWWVLNL TGNRIYNPNS QALELVVFND KVSPPSLGFL AGYGIMGLYA 2700
SVVLVIGKFV REFFSGISHS IMFEELPNVD RILKLCTDIF LVRETGELEL EEDLYAKLIF 2760
LYRSPETMIK WTREKTN 2777 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005261; F:cation channel activity; IEA:Compara.
 GO:0008381; F:mechanically-gated ion channel activity; IEA:Compara.
 GO:0006812; P:cation transport; ISS:UniProtKB.
 GO:0042391; P:regulation of membrane potential; IEA:Compara. 
Interpro
 IPR027272; Piezo. 
Pfam
 PF12166; DUF3595 
SMART
  
PROSITE
  
PRINTS