Tag | Content |
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CPLM ID | CPLM-021399 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Piezo-type mechanosensitive ion channel component 2 |
Protein Synonyms/Alias | Protein FAM38B |
Gene Name | PIEZO2 |
Gene Synonyms/Alias | C18orf30; C18orf58; FAM38B |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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2173 | KRELYMEKLQEHLIK | ubiquitination | [1] |
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Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons (By similarity). |
Sequence Annotation | CARBOHYD 95 95 N-linked (GlcNAc...) (Potential). CARBOHYD 1013 1013 N-linked (GlcNAc...) (Potential). CARBOHYD 1085 1085 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2752 AA |
Protein Sequence | MASEVVCGLI FRLLLPICLA VACAFRYNGL SFVYLIYLLL IPLFSEPTKT TMQGHTGRLL 60 KSLCFISLSF LLLHIIFHIT LVSLEAQHRI APGYNCSTWE KTFRQIGFES LKGADAGNGI 120 RVFVPDIGMF IASLTIWLLC RNIVQKPVTD EAAQSNPEFE NEELAEGEKI DSEEALIYEE 180 DFNGGDGVEG ELEESTKLKM FRRLASVASK LKEFIGNMIT TAGKVVVTIL LGSSGMMLPS 240 LTSSVYFFVF LGLCTWWSWC RTFDPLLFSC LCVLLAIFTA GHLIGLYLYQ FQFFQEAVPP 300 NDYYARLFGI KSVIQTDCSS TWKIIVNPDL SWYHHANPIL LLVMYYTLAT LIRIWLQEPL 360 VQDEGTKEED KALACSPIQI TAGRRRSLWY ATHYPTDERK LLSMTQDDYK PSDGLLVTVN 420 GNPVDYHTIH PSLPMENGPG KADLYSTPQY RWEPSDESSE KREEEEEEKE EFEEERSREE 480 KRSIKVHAMV SVFQFIMKQS YICALIAMMA WSITYHSWLT FVLLIWSCTL WMIRNRRKYA 540 MISSPFMVVY GNLLLILQYI WSFELPEIKK VPGFLEKKEP GELASKILFT ITFWLLLRQH 600 LTEQKALQEK EALLSEVKIG SQENEEKDEE LQDIQVEGEP KEEEEEEAKE EKQERKKVEQ 660 EEAEEEDEQD IMKVLGNLVV AMFIKYWIYV CGGMFFFVSF EGKIVMYKII YMVLFLFCVA 720 LYQVHYEWWR KILKYFWMSV VIYTMLVLIF IYTYQFENFP GLWQNMTGLK KEKLEDLGLK 780 QFTVAELFTR IFIPTSFLLV CILHLHYFHD RFLELTDLKS IPSKEDNTIY SHAKVNGRVY 840 LIINSIKKKL PIHQNELAHP EGSLPDLTMM HLTASLEKPE VRKLAEPGEE KLEGYSEKAQ 900 KGDLGKDSEE SEEDGEEEEE SEEEEETSDL RNKWHLVIDR LTVLFLKFLE YFHKLQVFMW 960 WILELHIIKI VSSYIIWVSV KEVSLFNYVF LISWAFALPY AKLRRLASSV CTVWTCVIIV 1020 CKMLYQLQTI KPENFSVNCS LPNENQTNIP FNELNKSLLY SAPIDPTEWV GLRKSSPLLV 1080 YLRNNLLMLA ILAFEVTIYR HQEYYRGRNN LTAPVSRTIF HDITRLHLDD GLINCAKYFI 1140 NYFFYKFGLE TCFLMSVNVI GQRMDFYAMI HACWLIAVLY RRRRKAIAEI WPKYCCFLAC 1200 IITFQYFICI GIPPAPCRDY PWRFKGASFN DNIIKWLYFP DFIVRPNPVF LVYDFMLLLC 1260 ASLQRQIFED ENKAAVRIMA GDNVEICMNL DAASFSQHNP VPDFIHCRSY LDMSKVIIFS 1320 YLFWFVLTII FITGTTRISI FCMGYLVACF YFLLFGGDLL LKPIKSILRY WDWLIAYNVF 1380 VITMKNILSI GACGYIGTLV HNSCWLIQAF SLACTVKGYQ MPAANSPCTL PSGEAGIIWD 1440 SICFAFLLLQ RRVFMSYYFL HVVADIKASQ ILASRGAELF QATIVKAVKA RIEEEKKSMD 1500 QLKRQMDRIK ARQQKYKKGK ERMLSLTQEP GEGQDMQKLS EEDDEREADK QKAKGKKKQW 1560 WRPWVDHASM VRSGDYYLFE TDSEEEEEEE LKKEDEEPPR RSAFQFVYQA WITDPKTALR 1620 QRHKEKKRSA REERKRRRKG SKEGPVEWED REDEPIKKKS DGPDNIIKRI FNILKFTWVL 1680 FLATVDSFTT WLNSISREHI DISTVLRIER CMLTREIKKG NVPTRESIHM YYQNHIMNLS 1740 RESGLDTIDE HPGAASGAQT AHRMDSLDSH DSISSEPTQC TMLYSRQGTT ETIEEVEAEQ 1800 EEEAGSTAPE PREAKEYEAT GYDVGAMGAE EASLTPEEEL TQFSTLDGDV EAPPSYSKAV 1860 SFEHLSFGSQ DDSAGKNRMA VSPDDSRTDK LGSSILPPLT HELTASELLL KKMFHDDELE 1920 ESEKFYVGQP RFLLLFYAMY NTLVARSEMV CYFVIILNHM VSASMITLLL PILIFLWAML 1980 SVPRPSRRFW MMAIVYTEVA IVVKYFFQFG FFPWNKNVEV NKDKPYHPPN IIGVEKKEGY 2040 VLYDLIQLLA LFFHRSILKC HGLWDEDDMT ESGMAREESD DELSLGHGRR DSSDSLKSIN 2100 LAASVESVHV TFPEQQTAVR RKRSGSSSEP SQRSSFSSNR SQRGSTSTRN SSQKGSSVLS 2160 IKQKGKRELY MEKLQEHLIK AKAFTIKKTL EIYVPIKQFF YNLIHPEYSA VTDVYVLMFL 2220 ADTVDFIIIV FGFWAFGKHS AAADITSSLS EDQVPGPFLV MVLIQFGTMV VDRALYLRKT 2280 VLGKVIFQVI LVFGIHFWMF FILPGVTERK FSQNLVAQLW YFVKCVYFGL SAYQIRCGYP 2340 TRVLGNFLTK SYNYVNLFLF QGFRLVPFLT ELRAVMDWVW TDTTLSLSSW ICVEDIYAHI 2400 FILKCWRESE KRYPQPRGQK KKKVVKYGMG GMIIVLLICI VWFPLLFMSL IKSVAGVINQ 2460 PLDVSVTITL GGYQPIFTMS AQQSQLKVMD QQSFNKFIQA FSRDTGAMQF LENYEKEDIT 2520 VAELEGNSNS LWTISPPSKQ KMIHELLDPN SSFSVVFSWS IQRNLSLGAK SEIATDKLSF 2580 PLKNITRKNI AKMIAGNSTE SSKTPVTIEK IYPYYVKAPS DSNSKPIKQL LSENNFMDIT 2640 IILSRDNTTK YNSEWWVLNL TGNRIYNPNS QALELVVFND KVSPPSLGFL AGYGIMGLYA 2700 SVVLVIGKFV REFFSGISHS IMFEELPNVD RILKLCTDIF LVRETGELEL EEDLYAKLIF 2760 LYRSPETMIK WTREKTN 2777 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005261; F:cation channel activity; IEA:Compara. GO:0008381; F:mechanically-gated ion channel activity; IEA:Compara. GO:0006812; P:cation transport; ISS:UniProtKB. GO:0042391; P:regulation of membrane potential; IEA:Compara. |
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