CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036611
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Lipid-phosphate phosphatase 
Protein Synonyms/Alias
  
Gene Name
 EPHX2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55GATTRLMKGEITLSQubiquitination[1]
79RKCSETAKVCLPKNFubiquitination[1]
84TAKVCLPKNFSIKEIubiquitination[1, 2]
89LPKNFSIKEIFDKAIubiquitination[1]
94SIKEIFDKAISARKIubiquitination[1]
174KFLLDTLKASPSEVVubiquitination[1]
191DDIGANLKPARDLGMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MTLRAAVFDL DGVLALPAVF GVLGRTEEAL ALPRGLLNDA FQKGGPEGAT TRLMKGEITL 60
SQWIPLMEEN CRKCSETAKV CLPKNFSIKE IFDKAISARK INRPMLQAAL MLRKKGFTTA 120
ILTNTWLDDR AERDGLAQLM CELKMHFDFL IESCQVGMVK PEPQIYKFLL DTLKASPSEV 180
VFLDDIGANL KPARDLGMVT ILVQDTDTAL KELEKVTGIQ LLNTPAPLPT SCNPSDMSHG 240
YVTVKIPALA QAGYRVLAMD MKGYGESSAP PEIEEYCMEV LCKEMVTFLD KLGLSQAVFI 300
GHDWGGMLVW YMALFYPERV RAVASLNTPF IPANPNMSPL ESIKANPVFD YQLYFQEPGV 360
AEAELEQNLS RTFKSLFRAS DESVLSMHKV CEAGGLFVNS PEEPSLSRMV TEEEIQFYVQ 420
QFKKSGFRGP LNWYRNMERN WKWACKSLGR KILIPALMVT AEKDFVLVPQ MSQHMEDWIP 480
HLKRGHIEDC GHWTQMDKPT EVNQILIKWL DSDARNPPVV SKM 523 
Gene Ontology
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0016787; F:hydrolase activity; IEA:InterPro. 
Interpro
 IPR000073; AB_hydrolase_1.
 IPR023214; HAD-like_dom.
 IPR006402; HAD-SF_hydro_IA_v3.
 IPR011945; HAD-SF_ppase_IA/epoxid_hydro_N.
 IPR005833; Haloacid_DH/epoxide_hydro.
 IPR023198; PGP_dom2. 
Pfam
 PF00561; Abhydrolase_1
 PF13419; HAD_2 
SMART
  
PROSITE
  
PRINTS
 PR00111; ABHYDROLASE.
 PR00413; HADHALOGNASE.