UniProt Accession

 CSRP3_MOUSE; P50462 

Genbank Protein ID

 Z49883; D88791; BC061131 

Genbank Nucleotide ID

 CAA90039.1; BAA13721.1; AAH61131.1 

Protein Name

 Cysteine and glycine-rich protein 3 

Protein Synonyms/Alias

 Cysteine-rich protein 3; CRP3; LIM domain protein, cardiac; Muscle LIM protein 

Gene Name

 Csrp3 

Gene Synonyms/Alias

 Clp; Mlp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	AKCGACEKTVYHAEE	ubiquitination	[1]
42	FHCMACRKALDSTTV	ubiquitination	[1]
109	ATTSNPSKFSAKFGE	ubiquitination	[1]
113	NPSKFSAKFGESEKC	ubiquitination	[1]
125	EKCPRCGKSVYAAEK	ubiquitination	[1]
169	KDGELYCKVCYAKNF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. 

Sequence Annotation

 DOMAIN 10 61 LIM zinc-binding 1.
 DOMAIN 120 171 LIM zinc-binding 2.
 MOTIF 64 69 Nuclear localization signal (Potential).  

Keyword

 Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; LIM domain; Metal-binding; Myogenesis; Nucleus; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0042805; F:actinin binding; IDA:BHF-UCL.
 GO:0008307; F:structural constituent of muscle; IMP:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
 GO:0003300; P:cardiac muscle hypertrophy; IEA:Compara.
 GO:0055003; P:cardiac myofibril assembly; IMP:BHF-UCL.
 GO:0006874; P:cellular calcium ion homeostasis; IGI:MGI.
 GO:0035995; P:detection of muscle stretch; IMP:BHF-UCL.
 GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
 GO:0033365; P:protein localization to organelle; IMP:BHF-UCL.
 GO:0002026; P:regulation of the force of heart contraction; IGI:MGI. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS