CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008518
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal transducer and activator of transcription 5B 
Protein Synonyms/Alias
  
Gene Name
 Stat5b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
701KAADGYVKPQIKQVVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription (By similarity). 
Sequence Annotation
 DOMAIN 589 686 SH2.
 MOD_RES 128 128 Phosphoserine (By similarity).
 MOD_RES 699 699 Phosphotyrosine; by HCK, JAK and PTK6 (By  
Keyword
 Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; SH2 domain; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 786 AA 
Protein Sequence
MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL 60
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV 120
REANNGSSPA GSLADAMSQK HLQINQTFEE LRLITQDTES ELKKLQQTQE YFIIQYQESL 180
RIQAQFAQLA QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL 240
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRLEHLC 300
QQLPIPGPVE EMLAEVNATI TDIISALSTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 360
NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS 420
LKRIKRSDRR GAESVTEEKF TILFDSQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA 480
TVLWDNAFRE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS 540
SSNHLEDYNS MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 600
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL 660
GDLNYLIYVF PDRPKDEVYS KYYTPVPCER ATAKAADGYV KPQIKQVVPE FVNASTDAGS 720
GATYMDQAPS PVVCPQAHYN MYPQNPDSVL DTDGDFDLED TMDVARRVEE LLGRPMDSQW 780
IPHAQS 786 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003690; F:double-stranded DNA binding; IDA:RGD.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:RGD.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0006103; P:2-oxoglutarate metabolic process; IEA:Compara.
 GO:0006953; P:acute-phase response; IDA:RGD.
 GO:0000255; P:allantoin metabolic process; IEA:Compara.
 GO:0006101; P:citrate metabolic process; IEA:Compara.
 GO:0006600; P:creatine metabolic process; IEA:Compara.
 GO:0046449; P:creatinine metabolic process; IEA:Compara.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0046543; P:development of secondary female sexual characteristics; IEA:Compara.
 GO:0046544; P:development of secondary male sexual characteristics; IEA:Compara.
 GO:0006631; P:fatty acid metabolic process; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0006549; P:isoleucine metabolic process; IEA:Compara.
 GO:0007259; P:JAK-STAT cascade; IDA:RGD.
 GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0001889; P:liver development; IDA:RGD.
 GO:0001553; P:luteinization; IDA:RGD.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Compara.
 GO:0006107; P:oxaloacetate metabolic process; IEA:Compara.
 GO:0048541; P:Peyer's patch development; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Compara.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0051272; P:positive regulation of cellular component movement; IMP:RGD.
 GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IEA:Compara.
 GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Compara.
 GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Compara.
 GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0042448; P:progesterone metabolic process; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0030856; P:regulation of epithelial cell differentiation; IEA:Compara.
 GO:0019218; P:regulation of steroid metabolic process; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0070672; P:response to interleukin-15; IEA:Compara.
 GO:0070669; P:response to interleukin-2; IEA:Compara.
 GO:0070670; P:response to interleukin-4; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IDA:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IDA:RGD.
 GO:0006105; P:succinate metabolic process; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0043029; P:T cell homeostasis; IEA:Compara.
 GO:0019530; P:taurine metabolic process; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IDA:RGD.
 GO:0006573; P:valine metabolic process; IEA:Compara. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR008967; p53-like_TF_DNA-bd.
 IPR000980; SH2.
 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd.
 IPR012345; STAT_TF_DNA-bd_sub.
 IPR013799; STAT_TF_prot_interaction. 
Pfam
 PF00017; SH2
 PF01017; STAT_alpha
 PF02864; STAT_bind
 PF02865; STAT_int 
SMART
 SM00252; SH2
 SM00964; STAT_int 
PROSITE
 PS50001; SH2 
PRINTS