| Tag | Content |
|---|
| CPLM ID | CPLM-017253 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-tubulin N-acetyltransferase |
Protein Synonyms/Alias | Alpha-TAT; TAT; Acetyltransferase mec-17 homolog |
Gene Name | Atat1 |
Gene Synonyms/Alias | Mec17 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 233 | KRAEGDIKPYSSSDR | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. |
Sequence Annotation | REGION 124 137 Acetyl-CoA binding (By similarity).
REGION 160 169 Acetyl-CoA binding (By similarity). |
Keyword | Alternative splicing; Complete proteome; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 421 AA |
Protein Sequence | MEFPFDVDAL FPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIVDEL GKASAKAQHL 60
PAPITSALRM QSNRHVIYIL KDTSARPAGK GAIIGFLKVG YKKLFVLDDR EAHNEVEPLC 120
ILDFYIHESV QRHGHGRELF QHMLQKERVE PHQLAIDRPS PKLLKFLNKH YNLETTVPQV 180
NNFVIFEGFF AHQHRPPTSS LRATRHSRAA VADPIPAAPA RKLPPKRAEG DIKPYSSSDR 240
EFLKVAVEPP WPLNRAPRRA TPPAHPPPRS SSLGNSPDRG PLRPFVPEQE LLRSLRLCPP 300
HPTARLLLAT DPGGSPAQRR RTRGTPWGLV AQSCHYSRHG GFNTSFLGTG NQERKQGEQE 360
AEDRSASEDR VLLLDGSGEE PTQTGAPRAQ APPPQSWTVG GDIMNARVIR NLQERRSTRP 420
W 421 |
Gene Ontology | GO:0019799; F:tubulin N-acetyltransferase activity; IDA:UniProtKB. GO:0071929; P:alpha-tubulin acetylation; IEA:InterPro. GO:0048666; P:neuron development; IEA:HAMAP. GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |