Tag | Content |
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CPLM ID | CPLM-021039 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | MARCKS-related protein |
Protein Synonyms/Alias | Brain protein F52; MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate; Mac-MARCKS; MacMARCKS |
Gene Name | Marcksl1 |
Gene Synonyms/Alias | Mlp |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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91 | ETPKKKKKFSFKKPF | acetylation | [1] | 95 | KKKKFSFKKPFKLSG | acetylation | [1] | 96 | KKKFSFKKPFKLSGL | acetylation | [1] | 99 | FSFKKPFKLSGLSFK | acetylation | [1] | 106 | KLSGLSFKRNRKEGG | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity). |
Sequence Annotation | REGION 87 110 Effector domain involved in lipid-binding REGION 87 100 Calmodulin-binding (PSD). MOD_RES 22 22 Phosphoserine (By similarity). MOD_RES 36 36 Phosphoserine (By similarity). MOD_RES 48 48 Phosphoserine (By similarity). MOD_RES 71 71 Phosphoserine (By similarity). MOD_RES 85 85 Phosphothreonine (By similarity). MOD_RES 93 93 Phosphoserine; by PKC (By similarity). MOD_RES 101 101 Phosphoserine; by PKC (By similarity). MOD_RES 104 104 Phosphoserine; by PKC (By similarity). MOD_RES 120 120 Phosphoserine; by MAPK8 (By similarity). MOD_RES 135 135 Phosphoserine (By similarity). MOD_RES 148 148 Phosphothreonine; by MAPK8 (By MOD_RES 151 151 Phosphoserine (By similarity). MOD_RES 162 162 Phosphoserine (By similarity). MOD_RES 165 165 Phosphoserine (By similarity). MOD_RES 183 183 Phosphothreonine; by MAPK8 (By MOD_RES 185 185 Phosphoserine (By similarity). LIPID 2 2 N-myristoyl glycine (By similarity). |
Keyword | Actin-binding; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Myristate; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 199 AA |
Protein Sequence | MGSQSSKAPR GDVTAEEAAG ASPAKANGQE NGHVKSNGDL TPKGEGESPP VNGADEAAGA 60 TGDAIEPAPP SQEAEAKGEV APKETPKKKK KFSFKKPFKL SGLSFKRNRK EGGGDSSASS 120 PTEEEQEQGE ISACSDEGTA QEGKAAATPE SQEPQAKGAE ASAVSKGGDA EEEAGPQAAE 180 PSTPSGPESG PASASAENE 199 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0016192; P:vesicle-mediated transport; IDA:RGD. |
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