CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gluconate 5-dehydrogenase 
Protein Synonyms/Alias
 5-keto-D-gluconate 5-reductase 
Gene Name
 idnO 
Gene Synonyms/Alias
 yjgU; b4266; JW4223 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
52RAELAVEKLHQEGIQacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes a reversible reduction of 5-ketoglutanate to form D-gluconate. Dependent on NADP, almost inactive with NAD. 
Sequence Annotation
 NP_BIND 13 37 NADP (By similarity).
 ACT_SITE 158 158 Proton acceptor (By similarity).
 BINDING 145 145 Substrate (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Gluconate utilization; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 254 AA 
Protein Sequence
MNDLFSLAGK NILITGSAQG IGFLLATGLG KYGAQIIIND ITAERAELAV EKLHQEGIQA 60
VAAPFNVTHK HEIDAAVEHI EKDIGPIDVL VNNAGIQRRH PFTEFPEQEW NDVIAVNQTA 120
VFLVSQAVTR HMVERKAGKV INICSMQSEL GRDTITPYAA SKGAVKMLTR GMCVELARHN 180
IQVNGIAPGY FKTEMTKALV EDEAFTAWLC KRTPAARWGD PQELIGAAVF LSSKASDFVN 240
GHLLFVDGGM LVAV 254 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008874; F:gluconate 5-dehydrogenase activity; IDA:EcoCyc.
 GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
 GO:0046183; P:L-idonate catabolic process; IEP:EcoCyc. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.