CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005226
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-galactosidase 
Protein Synonyms/Alias
 Acid beta-galactosidase; Lactase 
Gene Name
 Glb1 
Gene Synonyms/Alias
 Bgl; Glb-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
347EAGDLTKKYFALREVacetylation[1]
377TPKFAYGKVALRKFKacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441
Functional Description
 Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. 
Sequence Annotation
 ACT_SITE 189 189 Proton donor (Potential).
 ACT_SITE 269 269 Nucleophile (Potential).
 CARBOHYD 27 27 N-linked (GlcNAc...) (Potential).
 CARBOHYD 248 248 N-linked (GlcNAc...) (Potential).
 CARBOHYD 500 500 N-linked (GlcNAc...) (Potential).
 CARBOHYD 504 504 N-linked (GlcNAc...) (Potential).
 CARBOHYD 510 510 N-linked (GlcNAc...) (Potential).
 CARBOHYD 544 544 N-linked (GlcNAc...) (Potential).
 CARBOHYD 557 557 N-linked (GlcNAc...) (Potential).
 CARBOHYD 617 617 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Reference proteome; Signal; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 647 AA 
Protein Sequence
MLRVPLCTPL PLLALLQLLG AAHGIYNVTQ RTFKLDYSRD RFLKDGQPFR YISGSIHYFR 60
IPRFYWEDRL LKMKMAGLNA IQMYVPWNFH EPQPGQYEFS GDRDVEHFIQ LAHELGLLVI 120
LRPGPYICAE WDMGGLPAWL LEKQSIVLRS SDPDYLVAVD KWLAVLLPKM KPLLYQNGGP 180
IITVQVENEY GSYFACDYDY LRFLVHRFRY HLGNDVILFT TDGASEKMLK CGTLQDLYAT 240
VDFGTGNNIT QAFLVQRKFE PKGPLINSEF YTGWLDHWGK PHSTVKTKTL ATSLYNLLAR 300
GANVNLYMFI GGTNFAYWNG ANTPYEPQPT SYDYDAPLSE AGDLTKKYFA LREVIQMFKE 360
VPEGPIPPST PKFAYGKVAL RKFKTVAEAL GILCPNGPVK SLYPLTFTQV KQYFGYVLYR 420
TTLPQDCSNP KPIFSSPFNG VRDRAYVSVD GVPQGILDRN LMTALNIRGK AGATLDILVE 480
NMGRVNYGRF INDFKGLISN MTINSTVLTN WTVFPLNTEA MVRNHLWGRE ASDEGHLDGR 540
STSNSSDLIL PTFYVGNFSI PSGIPDLPQD TFIQFPGWSK GQVWINGFNL GRYWPTMGPQ 600
KTLFVPRNIL TTSAPNNITV LELEFAPCSE GTPELCTVEF VDTPVIS 647 
Gene Ontology
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0004565; F:beta-galactosidase activity; IDA:MGI.
 GO:0016936; F:galactoside binding; IEA:Compara.
 GO:0019388; P:galactose catabolic process; IEA:Compara. 
Interpro
 IPR026283; B-gal_1-like.
 IPR008979; Galactose-bd-like.
 IPR019801; Glyco_hydro_35_CS.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR001944; Glycoside_Hdrlase_35.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF01301; Glyco_hydro_35 
SMART
  
PROSITE
 PS01182; GLYCOSYL_HYDROL_F35 
PRINTS
 PR00742; GLHYDRLASE35.