UniProt Accession

 TAGL_HUMAN; Q01995; O15542 

Genbank Protein ID

 M95787; M83106; AF013711; D17409; D84342; BC004927; BC065829 

Genbank Nucleotide ID

 AAA58351.1; AAA58375.1; AAC21582.1; BAA21811.1; BAA21839.1; AAH04927.1; AAH65829.1 

Protein Name

 Transgelin 

Protein Synonyms/Alias

 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha; SM22-alpha 

Gene Name

 TAGLN 

Gene Synonyms/Alias

 SM22; WS3-10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	MSREVQSKIEKKYDE	acetylation	[1]
64	KNGVILSKLVNSLYP	ubiquitination	[2]
99	EQVAQFLKAAEDYGV	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence. 

Sequence Annotation

 DOMAIN 24 137 CH.
 REPEAT 175 200 Calponin-like.
 MOD_RES 2 2 N-acetylalanine (Potential).
 MOD_RES 166 166 Phosphoserine.  

Keyword

 Acetylation; Actin-binding; Complete proteome; Cytoplasm; Muscle protein; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0007517; P:muscle organ development; TAS:ProtInc. 

Interpro

 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin.
 IPR001061; TAGLN. 

Pfam

 PF00402; Calponin
 PF00307; CH 

SMART

 SM00033; CH 

PROSITE

 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 

PRINTS

 PR00888; SM22CALPONIN.