CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006683
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein-like 1 
Protein Synonyms/Alias
 GTP-binding protein HSR1 
Gene Name
 GNL1 
Gene Synonyms/Alias
 HSR1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
141PWSYEMSKEQLMSQEubiquitination[1]
158SFQDYLGKIHGAYSSubiquitination[2, 3, 4]
301CEAITVGKVDLSSWRubiquitination[1]
357GPTQERYKDGVVTIGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Possible regulatory or functional link with the histocompatibility cluster. 
Sequence Annotation
 DOMAIN 372 419 G.
 NP_BIND 225 228 GTP (Potential).
 NP_BIND 367 374 GTP (Potential).
 NP_BIND 411 415 GTP (Potential).
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 33 33 Phosphoserine.
 MOD_RES 34 34 Phosphoserine.
 MOD_RES 48 48 Phosphothreonine.
 MOD_RES 50 50 Phosphothreonine.
 MOD_RES 51 51 Phosphoserine.
 MOD_RES 68 68 Phosphoserine.
 MOD_RES 324 324 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 607 AA 
Protein Sequence
MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT SDGESVTHHI 60
RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA REQVLQPVSA ELLELDIREV 120
YQPGSVLDFP RRPPWSYEMS KEQLMSQEER SFQDYLGKIH GAYSSEKLSY FEHNLETWRQ 180
LWRVLEMSDI VLLITDIRHP VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH 240
YFHQHYPQLH VVLFTSFPRD PRTPQDPSSV LKKSRRRGRG WTRALGPEQL LRACEAITVG 300
KVDLSSWREK IARDVAGATW GNGSGEEEEE EDGPAVLVEQ QTDSAMEPTG PTQERYKDGV 360
VTIGCVGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT YFLTPSVKLC DCPGLIFPSL 420
LPRQLQVLAG IYPIAQIQEP YTAVGYLASR IPVQALLHLR HPEAEDPSAE HPWCAWDICE 480
AWAEKRGYKT AKAARNDVYR AANSLLRLAV DGRLSLCFHP PGYSEQKGTW ESHPETTELV 540
VLQGRVGPAG DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEETPTSAPG SSLAGRNPYA 600
LLGEDEC 607 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005615; C:extracellular space; NAS:UniProtKB.
 GO:0005525; F:GTP binding; NAS:UniProtKB.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0005198; F:structural molecule activity; NAS:UniProtKB.
 GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.
 GO:0042254; P:ribosome biogenesis; IBA:RefGenome.
 GO:0007165; P:signal transduction; NAS:UniProtKB.
 GO:0002456; P:T cell mediated immunity; NAS:UniProtKB. 
Interpro
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01926; MMR_HSR1 
SMART
  
PROSITE
  
PRINTS