| Tag | Content |
|---|
| CPLM ID | CPLM-013422 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | BTB/POZ domain-containing protein KCTD8 |
Protein Synonyms/Alias | |
Gene Name | Kctd8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 144 | FQLTDLVKLLSPKVT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. |
Sequence Annotation | DOMAIN 44 122 BTB. |
Keyword | Alternative splicing; Cell junction; Cell membrane; Complete proteome; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MALKDTGSGG STILPISEMV SASSSPGAPL AAAPGPCAPS PFPEVVELNV GGQVYVTKHS 60
TLLSVPDSTL ASMFSPSSPR GGARRRGDLP RDSRARFFID RDGFLFRYVL DYLRDKQLAL 120
PEHFPEKERL LREAEFFQLT DLVKLLSPKV TKQNSLNDEC CQSDLEDNVS QGSSDALLLR 180
GAAAGAPSGS GAHGVSGVVG GGSAPDKRSG FLTLGYRGSY TTVRDNQADA KFRRVARIMV 240
CGRIALAKEV FGDTLNESRD PDRQPEKYTS RFYLKFTYLE QAFDRLSEAG FHMVACNSSG 300
TAAFVNQYRD DKIWSSYTEY IFFRPPQKIV SPKQEHEDRK RDKVTDKGSE SGTSCNELST 360
SSCDSHSEAS TPQDNPANTQ QAAAHQPNTL TLDRPSRKAP VQWMPPPDKR RNSELFQSLI 420
SKSRETNLSK KKVCEKLSVE EEMKKCIQDF KKIHIPDCFP ERKRQWQSEL LQKYGL 476 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell. GO:0043235; C:receptor complex; IDA:MGI. GO:0051260; P:protein homooligomerization; IEA:InterPro. GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |