CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014925
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ral GTPase-activating protein subunit alpha-1 
Protein Synonyms/Alias
 GAP-related-interacting partner to E12; GRIPE; GTPase-activating Rap/Ran-GAP domain-like 1; Tuberin-like protein 1; p240 
Gene Name
 RALGAPA1 
Gene Synonyms/Alias
 GARNL1; KIAA0884; TULIP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1984INASRALKSLIPLYQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). 
Sequence Annotation
 DOMAIN 1796 2004 Rap-GAP.
 REGION 1327 2035 Minimal domain that binds to TCF3/E12 (By
 MOD_RES 754 754 Phosphothreonine.
 MOD_RES 773 773 Phosphoserine.
 MOD_RES 778 778 Phosphothreonine.
 MOD_RES 797 797 Phosphoserine.
 MOD_RES 860 860 Phosphoserine.
 MOD_RES 861 861 Phosphoserine.
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 1000 1000 Phosphoserine (By similarity).
 MOD_RES 1002 1002 Phosphothreonine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; GTPase activation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2036 AA 
Protein Sequence
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE 60
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN 120
SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSA PQSEHGPRTL DNLINPPLNL 180
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL 240
FSHFKKYYLP YIFPNICKEN SLYHPILDIP QMRPKPHYVV IKKDAETNEA IYCTKEPFIK 300
ARVIVIRWLV SFWLEPKPHT GPHIPGMEGE VLPKNIQRAA ASLVSREESK NDNADKTDRT 360
TEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL 420
LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEEIVITSS DLPCIENVTD HDISMEEGEK 480
REEENGTNTA DHVRNSSWAK NGSYQGALHN ASEEATEQNI RAGTQAVLQV FIINSSNIFL 540
LEPANEIKNL LDEHTDMCKR ILNIYRYMVV QVSMDKKTWE QMLLVLLRVT ESVLKMPSQA 600
FLQFQGKKNM TLAGRLAGPL FQTLIVAWIK ANLNVYISRE LWDDLLSVLS SLTYWEELAT 660
EWSLTMETLT KVLARNLYSL DLSDLPLDKL SEQKQKKHKG KGVGHEFQKV SVDKSFSRGW 720
SRDQPGQAPM RQRSATTTGS PGTEKARSIV RQKTVDIDDA QILPRSTRVR HFSQSEETGN 780
EVFGALNEEQ PLPRSSSTSD ILEPFTVERA KVNKEDMSQK LPPLNSDIGG SSANVPDLMD 840
EFIAERLRSG NASTMTRRGS SPGSLEIPKD LPDILNKQNQ MRPIDDPGVP SEWTSPASAG 900
SSDLISSDSH SDSFSAFQYD GRKFDNFGFG TDTGVTSSAD VDSGSGHHQS AEEQEVASLT 960
TLHIDSETSS LNQQAFSAEV ATITGSESAS PVHSPLGSRS QTPSPSTLNI DHMEQKDLQL 1020
DEKLHHSVLQ TPDDLEISEF PSECCSVMAG GTLTGWHADV ATVMWRRMLG ILGDVNSIMD 1080
PEIHAQVFDY LCELWQNLAK IRDNLGISTD NLTSPSPPVL IPPLRILTPW LFKATMLTDK 1140
YKQGKLHAYK LICNTMKRRQ DVSPNRDFLT HFYNIMHCGL LHIDQDIVNT IIKHCSPQFF 1200
SLGLPGATML IMDFIVAAGR VASSAFLNAP RVEAQVLLGS LVCFPNLYCE LPSLHPNIPD 1260
VAVSQFTDVK ELIIKTVLSS ARDEPSGPAR CVALCSLGIW ICEELVHESH HPQIKEALNV 1320
ICVSLKFTNK TVAHVACNML HMLVHYVPRL QIYQPDSPLK IIQILIATIT HLLPSTEASS 1380
YEMDKRLVVS LLLCLLDWIM ALPLKTLLQP FHATGAESDK TEKSVLNCIY KVLHGCVYGA 1440
QCFSNPRYFP MSLSDLASVD YDPFMHLESL KEPEPLHSPD SERSSKLQPV TEVKTQMQHG 1500
LISIAARTVI THLVNHLGHY PMSGGPAMLT SQVCENHDNH YSESTELSPE LFESPNIQFF 1560
VLNNTTLVSC IQIRSEENMP GGGLSAGLAS ANSNVRIIVR DLSGKYSWDS AILYGPPPVS 1620
GLSEPTSFML SLSHQEKPEE PPTSNECLED ITVKDGLSLQ FKRFRETVPT WDTIRDEEDV 1680
LDELLQYLGV TSPECLQRTG ISLNIPAPQP VCISEKQEND VINAILKQHT EEKEFVEKHF 1740
NDLNMKAVEQ DEPIPQKPQS AFYYCRLLLS ILGMNSWDKR RSFHLLKKNE KLLRELRNLD 1800
SRQCRETHKI AVFYVAEGQE DKHSILTNTG GSQAYEDFVA GLGWEVNLTN HCGFMGGLQK 1860
NKSTGLTTPY FATSTVEVIF HVSTRMPSDS DDSLTKKLRH LGNDEVHIVW SEHTRDYRRG 1920
IIPTEFGDVL IVIYPMKNHM FSIQIMKKPE VPFFGPLFDG AIVNGKVLPI MVRATAINAS 1980
RALKSLIPLY QNFYEERARY LQTIVQHHLE PTTFEDFAAQ VFSPAPYHHL PSDAGSYPEI 2040
LPSETPTATQ VDGADLASPM SPRTSKSRMS MKLRRSSGSA NKS 2083 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0017123; F:Ral GTPase activator activity; ISS:UniProtKB.
 GO:0032859; P:activation of Ral GTPase activity; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:Compara. 
Interpro
 IPR000331; Rap_GAP_dom.
 IPR027107; Tuberin/Ral-act_asu. 
Pfam
 PF02145; Rap_GAP 
SMART
  
PROSITE
 PS50085; RAPGAP 
PRINTS