UniProt Accession

 KAD3_RAT; P29411 

Genbank Protein ID

 D13062 

Genbank Nucleotide ID

 BAA02379.1 

Protein Name

 GTP:AMP phosphotransferase AK3, mitochondrial 

Protein Synonyms/Alias

 Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1 

Gene Name

 Ak3 

Gene Synonyms/Alias

 Ak3l1; Akl3l 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
29	TGSSRITKHFELKHL	acetylation	[1]
34	ITKHFELKHLSSGDL	acetylation	[1]
80	RLALHELKNLTQCSW	acetylation	[1]
165	LIQREDDKPETVIKR	acetylation	[1]
171	DKPETVIKRLKAYEA	acetylation	[1]
174	ETVIKRLKAYEAQTE	acetylation	[1]
189	PVLQYYQKKGVLETF	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities (By similarity). 

Sequence Annotation

 NP_BIND 17 22 GTP (By similarity).
 NP_BIND 64 66 AMP (By similarity).
 NP_BIND 91 94 AMP (By similarity).
 NP_BIND 137 138 GTP (By similarity).
 REGION 37 66 NMPbind (By similarity).
 REGION 127 164 LID (By similarity).
 BINDING 38 38 AMP (By similarity).
 BINDING 43 43 AMP (By similarity).
 BINDING 98 98 AMP (By similarity).
 BINDING 128 128 GTP (By similarity).
 BINDING 161 161 AMP (By similarity).
 BINDING 172 172 AMP (By similarity).
 BINDING 201 201 GTP; via carbonyl oxygen (By similarity).
 MOD_RES 34 34 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; GTP-binding; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.
 GO:0005759; C:mitochondrial matrix; IDA:RGD.
 GO:0004017; F:adenylate kinase activity; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0046899; F:nucleoside triphosphate adenylate kinase activity; IEA:EC.
 GO:0006172; P:ADP biosynthetic process; IDA:RGD.
 GO:0006756; P:AMP phosphorylation; IDA:RGD.
 GO:0021549; P:cerebellum development; IEP:RGD.
 GO:0046060; P:dATP metabolic process; IDA:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0007517; P:muscle organ development; IEP:RGD.
 GO:0021772; P:olfactory bulb development; IEP:RGD.
 GO:0051260; P:protein homooligomerization; IDA:RGD.
 GO:0042594; P:response to starvation; IEP:RGD. 

Interpro

 IPR006259; Adenyl_kin_sub.
 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK
 PF05191; ADK_lid 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.