CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017497
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-Y-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 CCNYL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
94ASTIFLSKSQTDVREubiquitination[1, 2, 3]
316FLFAPLSKERAQNLEubiquitination[4, 5]
332ISRLCEDKDLCRAAMubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
 DOMAIN 145 267 Cyclin N-terminal.
 MOD_RES 105 105 Phosphoserine.
 MOD_RES 112 112 Phosphoserine.
 MOD_RES 344 344 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cyclin; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MGNTLTCCVS PNASPKLGRR AGSAELYCAS DIYEAVSGDA VAVAPAVVEP AELDFGEGEG 60
HHLQHISDRE MPEDLALESN PSDHPRASTI FLSKSQTDVR EKRKSNHLNH VSPGQLTKKY 120
SSCSTIFLDD STVSQPNLRT TVKCVTLAIY YHIKNRDANR SLDIFDERSH PLTREKVPEE 180
YFKHDPEHKF IYRFVRTLFS AAQLTAECAI VTLVYLERLL TYAEIDICPT NWKRIVLGAI 240
LLASKVWDDQ AVWNVDYCQI LKDITVEDMN EMERHFLELL QFNINVPASV YAKYYFDLRS 300
LADDNNLNFL FAPLSKERAQ NLEAISRLCE DKDLCRAAMR RSFSADNFIG IQRSKAILS 359 
Gene Ontology
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR013763; Cyclin-like.
 IPR006671; Cyclin_N.
 IPR012399; Cyclin_Y. 
Pfam
 PF00134; Cyclin_N 
SMART
 SM00385; CYCLIN 
PROSITE
 PS00292; CYCLINS 
PRINTS