CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014896
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tetratricopeptide repeat protein 19, mitochondrial 
Protein Synonyms/Alias
 TPR repeat protein 19 
Gene Name
 TTC19 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
251ARYLLFSKQPSQAQRubiquitination[1, 2, 3]
346EIYQEALKQAKLKKDubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Mitochondrial protein required for formation of the mitochondrial complex III (PubMed:21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed:20208530). However, the involvement in cytokinesis requires additional experimental evidence. 
Sequence Annotation
 REPEAT 136 169 TPR 1.
 REPEAT 179 212 TPR 2.
 REPEAT 237 270 TPR 3.
 REPEAT 279 312 TPR 4.
 REPEAT 318 351 TPR 5.  
Keyword
 Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; TPR repeat; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 380 AA 
Protein Sequence
MFRLLSWSLG RGFLRAAGRR CRGCSARLLP GLAGGPGPEV QVPPSRVAPH GRGPGLLPLL 60
AALAWFSRPA AAEEEEQQGA DGAAAEDGAD EAEAEIIQLL KRAKLSIMKD EPEEAELILH 120
DALRLAYQTD NKKAITYTYD LMANLAFIRG QLENAEQLFK ATMSYLLGGG MKQEDNAIIE 180
ISLKLASIYA AQNRQEFAVA GYEFCISTLE EKIEREKELA EDIMSVEEKA NTHLLLGMCL 240
DACARYLLFS KQPSQAQRMY EKALQISEEI QGERHPQTIV LMSDLATTLD AQGRFDEAYI 300
YMQRASDLAR QINHPELHMV LSNLAAVLMH RERYTQAKEI YQEALKQAKL KKDEISVQHI 360
REELAELSKK SRPLTNSVKL 380 
Gene Ontology
 GO:0005813; C:centrosome; TAS:UniProtKB.
 GO:0030496; C:midbody; TAS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
 GO:0000910; P:cytokinesis; TAS:UniProtKB.
 GO:0034551; P:mitochondrial respiratory chain complex III assembly; IMP:UniProtKB. 
Interpro
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2. 
Pfam
 PF07719; TPR_2 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS