CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031679
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Basic leucine zipper and W2 domain-containing protein 2 
Protein Synonyms/Alias
 Basic leucine zipper and W2 domains 2, isoform CRA_b 
Gene Name
 BZW2 
Gene Synonyms/Alias
 hCG_19293 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38QSVDHFAKYFTDAGLubiquitination[1]
46YFTDAGLKELSDFLRubiquitination[2, 3, 4]
66GTRKELQKELQERLSubiquitination[5]
126LVAEQALKHLKQYAPubiquitination[1]
164YDNIHFMKAFQKIVVubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 225 AA 
Protein Sequence
MAEKDANSVT SSLRKANLDK RLLELFPVNR QSVDHFAKYF TDAGLKELSD FLRVQQSLGT 60
RKELQKELQE RLSQECPIKE VVLYVKEEMK RNDLPETAVI GLLWTCIMNA VEWNKKEELV 120
AEQALKHLKQ YAPLLAVFSS QGQSELILLQ KVQEYCYDNI HFMKAFQKIV VLFYKADVLS 180
EEAILKWYKE AHVAKGKSVF LDQMKKFVEW LQNAEEESES EGEEN 225 
Gene Ontology
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003307; W2_domain. 
Pfam
 PF02020; W2 
SMART
 SM00515; eIF5C 
PROSITE
 PS51363; W2 
PRINTS