CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001053
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glycylpeptide N-tetradecanoyltransferase 1 
Protein Synonyms/Alias
 Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; Type I N-myristoyltransferase; Peptide N-myristoyltransferase 1 
Gene Name
 Nmt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
80STQDQPVKMTSLPAEubiquitination[1]
94ERIQEIQKAIELFSVubiquitination[1]
107SVGQGPAKTMEEASKubiquitination[1]
305HRSLNPRKLIEVKFSacetylation[2]
310PRKLIEVKFSHLSRNacetylation[2]
310PRKLIEVKFSHLSRNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. 
Sequence Annotation
 MOD_RES 31 31 Phosphoserine.
 MOD_RES 47 47 Phosphoserine (By similarity).  
Keyword
 Acyltransferase; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 496 AA 
Protein Sequence
MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDNS HNRSGLSPAN DTGAKKKKKK 60
QKKKKEKGSD MESTQDQPVK MTSLPAERIQ EIQKAIELFS VGQGPAKTME EASKRSYQFW 120
DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY TLPQGFTWDA LDLGDRGVLK ELYTLLNENY 180
VEDDDNMFRF DYSPEFLLWA LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK 240
KMVEINFLCV HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS 300
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH QLLSRYLKQF 360
HLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF YTLPSTIMNH PTHKSLKAAY 420
SFYNVHTQTP LLDLMSDALV LAKMKGFDVF NALDLMENKT FLEKLKFGIG DGNLQYYLYN 480
WKCPSMGAEK VGLVLQ 496 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:Compara.
 GO:0030054; C:cell junction; IEA:Compara.
 GO:0005737; C:cytoplasm; TAS:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004379; F:glycylpeptide N-tetradecanoyltransferase activity; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0018008; P:N-terminal peptidyl-glycine N-myristoylation; ISA:MGI. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR000903; MyristoylCoA_TrFase.
 IPR022677; MyristoylCoA_TrFase_C.
 IPR022678; MyristoylCoA_TrFase_CS.
 IPR022676; MyristoylCoA_TrFase_N. 
Pfam
 PF01233; NMT
 PF02799; NMT_C 
SMART
  
PROSITE
 PS00975; NMT_1
 PS00976; NMT_2 
PRINTS