CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033390
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cathepsin D light chain 
Protein Synonyms/Alias
  
Gene Name
 CTSD 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13VDRIPLHKFTSIRRTubiquitination[1]
39IAKGPVSKYSQAVPAubiquitination[1]
169QVFGEATKQPGITFIubiquitination[1, 2]
238MLGGTDSKYYKGSLSubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aspartyl protease; Complete proteome; Disulfide bond; Hydrolase; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
MPRPVVDRIP LHKFTSIRRT MSEVGGSVED LIAKGPVSKY SQAVPAVTEG PIPEVLKNYM 60
DAQYYGEIGI GTPPQCFTVV FDTGSSNLWV PSIHCKLLDI ACWIHHKYNS DKSSTYVKNG 120
TSFDIHYGSG SLSGYLSQDT VSVPCQSASS ASALGGVKVE RQVFGEATKQ PGITFIAAKF 180
DGILGMAYPR ISVNNVLPVF DNLMQQKLVD QNIFSFYLSR DPDAQPGGEL MLGGTDSKYY 240
KGSLSYLNVT RKAYWQVHLD QVEVASGLTL CKEGCEAIVD TGTSLMVGPV DEVRELQKA 299 
Gene Ontology
 GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001461; Peptidase_A1.
 IPR021109; Peptidase_aspartic.
 IPR001969; Peptidase_aspartic_AS.
 IPR012848; Propep_A1. 
Pfam
 PF07966; A1_Propeptide
 PF00026; Asp 
SMART
  
PROSITE
 PS00141; ASP_PROTEASE 
PRINTS
 PR00792; PEPSIN.